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Multi-scale analysis for microscopic models in materials science and cell biology

Posted on:2001-03-11Degree:Ph.DType:Dissertation
University:University of Massachusetts AmherstCandidate:Kho, Alvin Thong-JuakFull Text:PDF
GTID:1468390014958536Subject:Mathematics
Abstract/Summary:
In Part I, we study the effects of random fluctuations included in microscopic models for phase transitions, to macroscopic interface flows. We first derive asymptotically a stochastic mean curvature evolution law from the stochastic Ginzburg-Landau model and develop a corresponding level set formulation. Secondly we demonstrate numerically, using stochastic Ginzburg-Landau and Ising algorithms, that microscopic random perturbations resolve geometric and numerical instabilities in the event of non-uniqueness in the corresponding deterministic flow. In Part II, we analyze the effects of random local linker length variability on the global morphology of a very long, linear, homogeneous chromatin fiber that is modelled as a diffusion process which is parametrized by arclength under a suitable spatial re-scaling. We obtain a Fokker-Planck equation for the process whose solution, a probability density function describes the folding.
Keywords/Search Tags:Microscopic
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