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Chaihujialonggumuli Decoction Treatment Of Metabolic Syndrome Theoretical Study And Clinical Research

Posted on:2014-09-13Degree:DoctorType:Dissertation
Country:ChinaCandidate:Y S SongFull Text:PDF
GTID:1264330425963861Subject:TCM clinical basis
Abstract/Summary:PDF Full Text Request
Objective:①MS showed a sick syndrome have a common internal relations, conditioning Sanjiao treatment of metabolic syndrom,Triple burner for gas, sputum (wet) of channel characteristics for metabolic syndrome phlegm disease pathogenesis:gasification disorders, disorders of the air-water fluid transmission and cloth disorders, phlegm block. Triple burner through the inside and outside and down about trades and also clinical to correct wet metabolism through conditioning sanjiao method disorder, the body recovery the body fluid Zhou flow, blood Tom Lee Yin Pingyang secret status, so as to achieve the purpose of the treatment of metabolic syndrome. At the same time the organs sanjiao the Diagnosis and Treatment of thinking can also be the triple burner shaped mass of new ideas.②Chaihujialonggumuli Decoction phlegm-heat intrinsic type of MS clinical efficacy, but the lack of a system of clinical research, its clinical research can explore its effector mechanisms.Methods:clinical observation metabolic syndrome in43patients, Malaysia Yiyuan TCM clinics patients are in the April2012April2013, according to the principle of randomization divided into western medicine group (23cases) and group B (20cases). Observation of patients included in the patients on the basis of the diet and exercise therapy, respectively Decoction and pharmaceutical group Chaihujialonggumuli intervention, treatment period of2months, the comparison between the two groups and each group before and after, before and after metabolism comprehensive indicators levy various diagnostic indicators, clinical symptom scores, quality of life scale score improved after treatment, the use of data processing SPSS18.0package, count data using χ2test, measurement data using t-test.Results:(1) the efficacy of the total efficiency in the western medicine group was82.61%,60%in the western medicine group, there are significant differences between the two groups (P<001); between the two groups and the symptom score improvement aspects, in the western medicine group was significantly better than western medicine group, two groups there is a significant difference (P<0.01), suggesting that more comprehensive than Western medicine, western medicine role in the diagnosis and treatment thought.(2) After treatment, all were significantly decreased (P<0.05), which, in Western medicine combined group2hPG and HOMA-IR decreased more significantly (P<0.01), indicating the two groups can improve the metabolic syndrome sugar metabolite levels between the two groups were compared, no significant difference (P>0.05) Overall, in the western medicine group is better than the comparison group in improving metabolic syndrome in patients with symptoms.(3) treatment, lipid metabolism, Chinese medicine combined group decreased significantly (P<0.05), including TC, TG decreased significantly (P<0.01). The WM group projects downward trend, but not statistically significant (P>0.05), compared with the group before treatment. Together, indicating that the two groups can improve the level of metabolic syndrome lipid metabolism. Between the two groups were compared, in medicine better efficacy of the combination group compared with the comparison group, compared with the comparison group, TC, TG significant difference (P <0.05), HDL-C and LDL-C difference was statistically significant. Overall, in the western medicine group in improving metabolic syndrome in patients with symptoms better than the comparison group.(4)treatment of inflammatory cytokines, each group after treatment than before treatment were decreased, compared with treatment of TNF-α and IL-6has a significant meaning in the western medicine group decreased. Between the two groups compared to the combination of Chinese and Western medicine group decreased more statistically significant difference test (P<0.01). Tip Bupleurum Plus Longgumuli soup better anti-inflammatory effect.Conclusions and Implications:①MS etiology, pathogenesis is very complex, and its incidence is the result of the interaction of multiple factors, with genetic, environmental and immunologic factors have a relationship. Lifestyle improvement is fundamental measures of prevention and treatment of metabolic syndrome. Medicine,"treating disease" medical thought and health science can bring a lot of new ideas for the prevention of MS, the new method:diagnosis and treatment system in medical diagnosis and treatment, can be multi-component, multi-link, multi-target integrated regulation of human The obvious advantage of an irreplaceable function in the prevention and cure MS, effective regulation, comprehensive treatment involving a wide range of metabolic disorders, and to improve the quality of life:traditional Chinese medicine has a natural, low toxicity, safe, inexpensive advantages. Has a natural advantage in the prevention and treatment of this disease. MS TCM clinical and experimental studies should be strengthened in the future. I believe that Chinese medicine will play a bigger role in the fight.②sanjiao form of quality despite the controversy, but the understanding of the physiological function of various basic. Triple burner has its separate clinical syndromes. Attention should be paid to clinical the various syndromes the San Jiao adversely appears, can not be subject to the "triple burner famous invisible" effect, ignore the diagnosis and treatment of the triple burner syndromes. The triple burner theory must be derived from clinical practice and clinical and clinical guide back this theory of practical significance.③from sanjiao level of theory to new understanding of Bupleurum plus Longgumuli Decoction Diagnosis and Treatment of flexibility and range of applications. Summary of the ancient and modern physicians have accumulated rich clinical experience in the diagnosis and treatment, the use of modern statistical analysis methods, systematic combing and profiling.
Keywords/Search Tags:metabolic syndrome, Chaihujialonggumuli soup, sanjiao, sanjiao theory, theoreticalstudy, clinical research
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