Study Drug Using Regularity Of Premature Ovarian Failure Based On Ancient And Modern Literature

ObjectiveBased on systematical arrangement of ancient literature and modem literature on premature ovarian failure, the literature research method, combined with modern data mining technology, is adopted to study the drug using regularity of traditional Chinese medicine treatment of premature ovarian failure, discuss the clinical features of ancient and modern Chinese medicine treatment of premature ovarian failure, and provide basis and guidance for the theoretical innovation and clinical study of diseases for which traditional Chinese medicine is advantageous.Methods①Literature research method:For the ancient literature, determine which Chinese medical books contain content related to traditional Chinese medicine syndrome differentiation and treatment of premature ovarian failure, and choose a better version as the basic literature material for the study; At the same time, use Traditional Chinese Medicine CD ROM to search "blood dry","infertility","the menses off early","amenorrhea","blood separation","absence of menses","not old by the menses off’, etc. as the index words; search traditional Chinese medicine literature associated with premature ovarian failure, screen out the prescriptions for premature ovarian failure treatment, and extract the relevant contents. For modern literature, use Chinese Journal Full-Text Database (CNKI) as the search term in the theme, with premature ovarian failure as the index words, collect all references related to traditional Chinese medicine diagnosis and treatment of premature ovarian failure, and screen out the prescriptions for treatment of premature ovarian failure.②Data mining method:The association rules in data mining are adopted. Firstly, the ancient prescriptions and modern prescriptions for treatment of premature ovarian failure collected by the means of literature research method are subject to data standardization processing, and it is mainly about the unity of Chinese medicine name. Secondly, enter the data material obtained by means of literature research and arrangement as well as standardized processing into the computer, index the relevant content, and make corresponding form (including list of ancient prescriptions for premature ovarian failure and list of modern prescriptions for premature ovarian failure). Finally use association rules to conduct data mining. PASW18is adopted for relevant data processing and analysis for this research.Results①This research combs the understanding of ancient traditional Chinese medicine towards the similar disease, etiology and pathogenesis of premature ovarian failure; summarizes the understanding of modern Chinese medicine towards etiology and pathogenesis of premature ovarian failure.②This research sorts out412ancient prescriptions for premature ovarian failure and191modern prescriptions for premature ovarian failure.③The core drugs used in ancient traditional Chinese medicine treatment of premature ovarian failure are angelica, rhizoma chuanxiong, radix paeoniae alba, poria, prepared rehmannia root, ginseng, etc. Angelica-rhizoma chuanxiong, angelica-radix paeoniae alba, angelica-prepared rehmannia root, rhizoma chuanxiong-radix paeoniae alba, angelica-radix glycyrrhizae, etc. are the core drug pairs. It points out that the ancient traditional Chinese medicine treatment of premature ovarian failure mainly bases on replenishing qi and blood.④The core drugs used in modern Chinese medicine treatment of premature ovarian failure are angelica, prepared rehmannia root, dodder seed, wolfberry fruit, Chinese yam, epimedium, etc. Angelica-prepared rehmannia root, prepared rehmannia root-dodder seed, wolfberry fruit-dodder seed, angelica-dodder seed, Chinese yam-prepared rehmannia root are the core drug pairs. It points out that the modern Chinese medicine treatment of premature ovarian failure mainly bases on nourishing the blood in liver and kidney.⑤The core drugs selected by both ancient and modern Chinese medicine treatment of premature ovarian failure are:Angelica, prepared rehmannia root, radix paeoniae alba and poria. Angelica-prepared rehmannia root is the core drug pair. It points out that both the ancient and modern Chinese medicine suggest that deficiency of blood is a pathological basis of the disease.⑥For the choice of drugs, modern Chinese medicine is more centralized compared to ancient traditional Chinese medicine, which is mainly reflected in the use of drugs tonifying kidney. And this demonstrates that modern Chinese medicine considers premature ovarian failure is mainly caused by kidney deficiency, and it emphasizes on treatment thought of tonifying the kidney. While the drugs range of ancient traditional Chinese medicine is wider, not focusing on tonifying kidney only in treatment, and it pays more attention to the relationship between the function of the human body organs, especially the relationship between heart, liver, spleen and kidney.⑦The ancient traditional Chinese medicine often combines interior-warming drugs such as aconite and cinnamon for the treatment. On the one hand, they can warm and smooth the passages through which vital energy circulates, and help the growth of Qi and blood, on the other hand they can conduct the fire back to its origin, which is used for deficient yang with upper manifestation. This provides new ideas for modern Chinese medicine treatment of premature ovarian failure.ConclusionLiterature research method combined with modern data mining method are adopted to study the drug using regularity in ancient and modern Chinese medicine for premature ovarian failure and this reveals the common ground and unique features of ancient and modern clinical medicine doctors. It points out that modern doctors, who mainly give priority to tonifying kidney in treatment of premature ovarian failure can also further discuss the etiology and pathogenesis and expand their treatment thoughts. The results of this method are clear and specific with definite direction, and it has good feasibility. In the future research work, people can continue to use this method for deeper exploration and research of the prescription compatibility regularity, and the object of study shall be expanded from drug composition to drug dosage and usage of the prescriptions, as well as the aspects such as etiology and pathogenesis, syndrome, therapy, rules of treatment, etc. for premature ovarian failure in order to make the study more comprehensive and systematical.