Clinical Characteristics Associated With Allergic Rhinitis Study In Guangdong Province

PurposeThrough clinical research and clinical characteristics of allergic rhinitis experimental comparison of different life cycle to arrive at the clinical characteristics of pediatric patients with allergic rhinitis, and predict disease trends allergic rhinitis. Used to guide diagnosis and treatment and improve efficacy.MethodsAll cases of this subject are from outpatient Guangzhou University of Traditional Chinese Medicine First Affiliated Hospital otorhinolaryngology September 2014 to February 2016 period, at least 3 years of age, a history of at least three months, after allergen post-test diagnosed with allergic rhinitis patients with a total 384 cases. All self-made "allergic rhinitis clinical features, TCM Survey" conducted by the tutor and live. The collection includes patients with nasal symptoms VAS score, family history, symptoms associated with allergic rhinitis and typing common TCM syndrome factors influence. In animal experiments, using the OVA sensitized BALB/c mice, a mouse model of allergic rhinitis manufactured by observing the mice scratching the nose of the number of different life cycle, compared to the severity of their allergy. Application of computer data entry EXCEL table, using SPSS 19.0 statistical software for analysis.ResultsAllergic rhinitis in pediatric patients in the medium-term oriented course, the course does not affect the body, mainly in children with slim, slim less than one-third of overweight, while medium size, its nasal itching, nasal congestion, runny tears lightest. The first two rows of the attack site is home, at school. And allergic rhinitis in adult patients with long-term course of the main body with the main medium-sized, slim body is about half of overweight, underweight people sneezing, runny nose lightest, shortest average duration. Whether children or adults are mainly in the early morning attack, regardless of the home. Gender is not a factor in the pathogenesis of allergic rhinitis.Whether children or adult patients with allergic rhinitis, the incidence of nasal symptoms of equivalent each; inferior turbinate swelling indexing without significant difference. Pediatric patients with allergic rhinitis, nasal congestion worst, runny nose followed. Inferior turbinate is 3 degrees, the average VAS score highest stuffy; inferior turbinate is 2 degrees or 3 degrees, the average duration of 1-0 degrees and 1 degree long,0 degree and could not explain the shorter duration. And adult patients with allergic rhinitis, with sneezing, runny nose symptoms led to more severe inferior turbinate swelling, nasal congestion, its average VAS score could be.Whether children or adult patients with allergic rhinitis, are after the first nasal itching eye itching, pruritus based, and itchy eyes and itchy skin each other risk factors, children with allergic rhinitis patients have no obvious relationship irritability; gender differences in the impact of irritability or not had no significant. Fear of the disease in patients and adult patients have an impact on children’s quality of life are over 60% In addition, adults are more worried about the disease affect the quality of sleep in patients than in children. Whether children or adult patients with allergic rhinitis, nasal congestion, snoring is more serious when combined; Additionally, nasal congestion is most likely to cause allergic rhinitis in pediatric patients worry about sleep, worry and irritability developmental factors. Allergic rhinitis after the first, the incidence of asthma in adults is 1.8 times that of children. Adults more than children with cold, cold regardless of the presence or absence of air conditioning at home, and the incidence of asthma is also irrelevant. Patients with allergic rhinitis in adult patients with a family history of children, history of asthma was no significant difference.Differences of syndromes and adult children with allergic rhinitis contrast are significant, and adult patients with allergic rhinitis in pediatric patients whose lung Deficiency Syndrome and temper weak evidence, the sum of the frequency of the incidence of Insufficiency of Qi Syndrome fairly, about 65%, but the children belong to spleen deficiency patients significantly more than adults, adults with children belonging to patients than lung accumulated heat syndrome with kidney deficiency syndrome and more. Early morning allergic rhinitis in pediatric patients with adult onset are based on Insufficiency of Qi Deficiency Syndrome with lung syndrome based, but belong to spleen deficiency syndrome in pediatric patients was significantly more than adults, adults belonging to the lung accumulated heat with renal syndrome multi-yang deficiency syndrome patients than children. Yang-deficient pediatric patients nasal itching, runny nose worst, sneezing lightest; sneezing heaviest children with lung Deficiency type; various syndromes were no significant differences in nasal congestion; temper weakness of adult patients with symptoms of runny nose the most serious. The combined incidence of snoring children with allergic rhinitis patients (14.09%) than in adult patients incidence (9.15%) higher for children with allergic rhinitis patients with snoring to temper weakness of the main places and adult patients lung Insufficiency of Qi Deficiency type and type-based; sinusitis in patients with allergic rhinitis children incidence (5.91%) higher than the incidence of adult patients (3.05%), allergic rhinitis, sinusitis patients with children in lung accumulated heat type and temper weakness of the main places Insufficiency of Qi and adult patients with type-based; allergic rhinitis in pediatric patients with asthma incidence (5.00%) than the incidence of adult patients (4.88%) slightly higher, allergic rhinitis patients with asthma primarily lung and stomach, spleen and lung deficiency, kidney deficiency syndromes mainly three kinds. Pediatric patients with allergic rhinitis accompanied by nasal itching, eye itching and pruritus incidence (19.09%) than in adult patients (9.14%), combined itchy eyes, itchy skin allergic rhinitis does not affect the distribution of TCM syndromesGuangdong region 384 patients with allergic rhinitis, either the patient or the patient adult children, their allergen top three are followed by house dust mites, dust mites and indoor dust, which, dust mites and household dust almost identical frequency distribution of mites, often at the same level and the same appears nothing to do with the distribution of TCM syndrome. Whether allergic rhinitis in pediatric patients or adults, milk, shrimp, cotton, crab, dog hair, cat hair these types of allergens, the allergy grade main level 1, and the positive rate of stage 1 is level 2 or even 2.5 times higher than the sum of the positive rate.Shrimp and crab, cat hair and dog hair, house dust mites and each other risk factors. Not a risk factor for cotton mite allergy.Nasal itching extent AR AR pregnant rats than in adult rats serious, and nasal itching severe degree older than younger rats AR AR rat; nasal itching degree of first-generation rat pups severe AR mice than normal mice, but better than AR to a lesser degree nasal itching female mice; mice during different life from preconception to postpartum experience, the symptoms of nasal itching at the beginning of the performance of the most serious post-natal, antenatal nasal itching has been aggravated, nasal itching postpartum began to gradually reduceConclusion1. Patients with allergic rhinitis and adult children of patients compared the clinical characteristics are inconsistent, pediatric patients, the most severe nasal congestion, runny nose, followed by adult patients, with sneezing, runny nose, led to symptoms.2. Patients with allergic rhinitis and adult children of patients whose lung Deficiency Syndrome and temper weak evidence, the sum of the frequency of the incidence of Insufficiency of Qi syndrome rather, about 65%, but the children belong to spleen deficiency patients significantly more than adults, adults multi-patient patients belong to Yun lung heat syndrome with kidney deficiency syndrome than children.3. Guangdong region 384 patients with allergic rhinitis, either the patient or the patient adult children, their allergen top three are followed by house dust mites, dust mites and indoor dust, which, dust mites and frequency distribution of house dust mites are almost the same, often appear at the same time and the same level, regardless of the distribution of TCM syndrome.4. Different mouse model of allergic rhinitis lifecycle, nasal itching extent older people than younger persons seriously female mice allergic rhinitis nasal itching in late pregnancy symptoms most severe after delivery, nasal itching symptoms will reduce.