The Research Of Clinical Experience Of Professor Zhang Bingxiu Diagnosis And Treatment Of Epigastric Pain Based On Data Mining

[Objective] Based on the TCM theory and clinical practices specialized by Professor Zhang Bingxiu who is one of the National old TCM, combined with modern advanced data mining technology and scientific testing methods, we study、heritage and develop the clinical experience and academic ideas accumulated by Professor Zhang Bingxiu treating epigastric pain. Improve the diagnosis and treatment of Chinese medicine in epigastric pain the clinical curative effect. Play old Chinese medicine experts in traditional Chinese medicine academic inheritance of specific role.[Methods]Has collected Professor Zhang Bing Xiu over the years of experience in the treatment of epigastric pain case, according to inclusion criteria, exclusion criteria screening will meet the standards of the640cases755times the clinical diagnosis in turn entered into the computer data, all data are classified, statistical analysis, establish the best medical record data mining models. For each specific software features and advantages of statistical software used SPSS15.0frequency analysis, cluster analysis, principal component analysis and factor analysis; use Microsoft SQL Server2005Data Mining Add-Ins for Office Excel2007Logistic regression analysis, association rules analysis.Frequency analysis involves syndromes, the four diagnostic information, pathogenesis, Chinese traditional medicine, course of disease, specific symptoms and medical history and other aspects.Hierarchical clustering, principal components and factor analysis is mainly used for further analysis of four diagnostic information.Logistic regression analysis is mainly used for analysis of syndromes and the relationship between traditional Chinese medicines.Association rules analysis is mainly used for the analysis of epigastric pain syndromes associated with the performance of endoscopic, pathogenesis associated with traditional Chinese medicine, the main symptoms associated with the traditional Chinese medicine.Organic combine the above methods for effective mining of medical record information and make a systemic interpretation of the corresponding laws of disease、syndrome、 symptoms and prescription and drugs. Finally we explore the syndrome differentiation thinking and law of prescription drugs which is based on the analysis of the mining results and combined with clinical experience of Professor Zhang Bingxiu.[Results]Data mining results are as follows:A total of227kinds of traditional Chinese medicine use. frequency of greater than20times only77species. Chinese medicine treatment methods are more, a total of475kinds, frequency20times greater than88species.Describes the treatment of choice of types of traditional Chinese medicine and Chinese medicine dose selection for a relatively fixed and focused.Most cases of a history of epigastric pain longer.There are219kinds of signs reflect the four diagnostic information, to reflect the elements of the signs of the syndrome in about60.Many patients choose zi ni decoction treatment, according to the corresponding syndrome shows the excessive pathogenic factors of these cases to the main condition.Epigastric pain with stomach, spleen, liver, gallbladder, kidney and other organs is closely related to five, with qi. deficiency, heat, dampness, cold, constraint and other pathological factors closely related; cluster and factor analysis resulting classification is not only signs of the syndrome, but also primary and secondary points, it is beneficial for the analysis of four diagnostic points to accurately grasp the dialectical Pathogenesis and syndromes:Come to the preliminary diagnostic programs of epigastric pain syndromes:syndrome of spleen-stomach deficiency cold based primarily on the cold pain,cold chills, thermophilic hi. deep pulse, thin tongue fur, pale red tongue, white tongue fur, a secondary basis epigastric upset, acid upflow, belching, fine pulse, fatigued spirit; syndrome of liver-QI invading the stomach based primarily on vexation, insomnia, like sighing, chest tightness, scurrying pain. emotional incentives, With and rib-side, distending pain, a secondary basis for distending pain with Breasts, dizziness;syndrome of damp-heat obstructing in zhong jiao based primarily on bitterness of mouth, dry mouth, yellow tongue fur, stringlike pulse, red tongue, inhibited defecation,dry stool, slippery pulse, a secondary basis for nausea, yellow urine, scorching pain heartburn;syndrome of deficiency of spleen-QI and stomach-QI based primarily on the pale tender-soft tongue, tongue bearing dental impressions, weak pulse, looking Shaohua. anorexia, moderate pulse,lack of strength, according to a small secondary little Moss, dull pain abdominal distention after eating;syndrome of phlegm-damp retention based primarily on somnolence, heavy cumbersome body, slimy tongue fur, mouth sticky, heavy sense of falling, loose stools, increased after eating, according to the secondary soggy pulse, thick fur:syndrome of retention of blood stasis based primarily on tingling pain, site fixed, dark purple tongue, rough pulse, stasis macule, secondary basis abdominal distention, press hard.Under epigastric pain various syndromes associated with the performance of endoscopic the connection rule findings confirmed Professor Zhang Bing Xiu proposed "the internal organs observation of patient’s complexion","examines into micro" and so on viewpoint usability; Will govern the law standard later fortify the spleen, clear heat, supplement qi. rectify qi,remove dampness, direct counter flow downward, warm the center, supplement yin,dissolve stasis, dissolve phlegm, promote gallbladder function, detoxification12methods are highlighted; Top20of the following prescription wei ai decoction,zi ni decoction.xuan fu dai zhe decoction,li zhong decoction.xiao yao powder,chai qin wen dan decoction,chai hu shu gan powder, wen dan decoction,pin wei powder.yu nv decoction,zuojin pill,fu zi li zhong decoction,xie huang powder,da chai hu decoction.zheng dan decoction,lin gui zhu gan decoction,shao yao gan cao decoction,shi xiao powder,xuan mai jie gan decoction, yi guan decoction;Logistic regression analysis showed that the syndrome is closely related with the drug order. And takes advantage of this summarizes related after the proven prescription.Treatment of syndrome of deficiency of spleen-QI and stomach-QI can choose Taizishen/Dangshen、Huangqi、Dazao、Muxiang for the experience; Treatment of syndrome of liver-QI invading the stomach can choose Chaihu、Xiangfu、Baishao、 Danggui、Qingpi、Muhudie、Bohe for the experience; Treatment of syndrome of damp-heat obstructing in zhong jiao can choose Huanglian、Huangqin、Zhizi、Yinchen、Tufuling、 Pugongying or the experience; Treatment of syndrome of spleen-stomach deficiency cold can choose Renshen、Paojiang/Ganjiang、Guizhi、Huangqi、mature Yiyiren、Muxiang for the experience; Treatment of syndrome of stomach yin deficiency can choose Beishashen、Maidong、 Taizishen、Shengdi、Mudanpi、Gouqizi、Wuweizi for the experience; Treatment of syndrome of retention of blood stasis can choose Puhuang、Wulingzhi、Jixueteng、Chishao、Danshen、 Huangqi for the experience; Treatment of syndrome of phlegm-damp retention can choose Cangzhu、raw Yiyiren、Lianzi、Shichangpu、Huoxiang、Banxia、Shengjiang for the experience; Treatment of syndrome of intense stomach-heat can choose Mudanpi、raw Shigao、Shengma、 Zhimu、Shengdi、Zhizi、Maidong for the experience; Treatment of syndrome of retention of food in stomach can choose Shanzha、Maiya、mature Yiyiren、Fuling、Lianqiao、Jiuxiangchaong for the experience; Treatment of syndrome of cold pathogen attacking stomach can choose Cangzhu、Shengjiang、Huoxiang、Jiuxiangchong、Dafupi for the experience.Summarizes the main clinical experience and academic thought as follows:That the spleen-stomach vacuity is a major cause of epigastric pain; That the relevant organs falling out, air-lift disorders are the main disease pathogenesis; Careful card for stressed because of the characteristics of the core syndrome grasp; Syndrome of deficiency of spleen-QI and stomach-QI be splitting up single intended to be a type, this point of view with the same strain Li Dongyuan attention to the spleen;Combined TCM and West Medicine proposed "the internal organs observation of patient’s complexion"; Embedded in the tonifying method in the method of free the bowels, so that the spleen-stomach enhancements;Epigastric pain treatment should be made mainly supplement vacuity, while focusing on free the bowels; Recipe unique can be compatible with ancient and modern, flexible ancient prescription created wei ai decoction, for clinical efficacy outstanding.[Conclusion]The results of data mining in general, reflect Professor Zhang Bingxiu the laws of the clinical treatment of epigastric pain. Diagnosis and treatment of epigastric pain that Professor Zhang Bingxiu characteristics and experience are the highlights and data support.Enrich the old Famous TCM experts’ Diagnosis and Treatment of epigastric pain of clinical experience and academic thinking for clinical practice to provide an objective basis. Data mining is used in Famous TCM experts’clinical experience collection to the new breakthroughs and new development.