On The Relevance Between The Northwest Dryness Syndrome And Heart System Diseases

Objectives: 1) to analyze the relationship of attack rate between the Northwest Dryness Syndrome and heart system diseases in Xinjiang Autonomous Region. 2) to analyze the correlation between the state of illness and syndrome of heart system diseases and NDS in Xinjiang. 3) to analyze the similarities and differences of the physique between the patients of NDS and heart system diseases and to reveal the impact of NDS on the patients’status of heart system diseases. Methods: By applying methods of philology analysis and clinical epidemiology, 1314 questionnaires were designed and collected. On the basis of case-control, disease group (486 cases) and control group (828 cases) are set up to compare the attack rate of northwest dryness syndrome (NDS), NDS integration, deficiency syndrome of Qi, blood, Yin and yang; to compare the state of illness, general syndrome differentiation in traditional Chinese medicine, integrations of NDS and deficiency syndrome of NDS group and non-NDS group in the disease group. After the collection of all questionnaires, all data were put into EPIDATA 3.0 and derived into SPSS 16.0 for statistic analysis. Equilibrium Analysis of demographic data is adopted in both disease group and control group. Enumeration data is analyzed by chi-square. Masurement data is analyzed by T-Test and analysis of variance. Heterogeneity of variance is analyzed with t’and Kruskal-Wallis testing method. Two-side test are applied in all statistic test. The tested difference will be considered to be Statistically Significant when P≤0.05. The significant level isα’ = 2α/k(k-1) when the enumeration data is pairwise compared among groups. Results: 1) The attack rate of NDS in heart disease group (37.86%) is higher than control group (18.47%) (χ~2=60.329, P<0.01). The same situation exists in all other disease groups. The attack rate of NDS ranks in descending order as follows: neurasthenia (62.65%), prurituscutanea (49.35%), coronary heart disease (31.48%), hypertension (31.37%), acne (24.13%). 2) The total integration of NDS in heart disease group is higher than control group (P<0.01). There is obvious difference on the NDS integrations of main and accompanying syndromes between these two groups except the lung and heart wind-fire pathogen syndrome, i.e. Disease group is higher than control group. Among all standardized mean differences of syndromes, the highest ones are yin deficiencies of the heart and kidney syndrome and skin and opening of the body syndrome. 3) The outer dryness syndrome in all disease groups but group of hypertension is higher than control groups (P<0.05), especially prurituscutanea and acne. The integrations of inner dryness syndrome of coronary heart disease, hypertension and neurasthenia are higher than that of outer dryness syndrome (P<0.05). The comparison between the integrations of inner dryness syndrome of prurituscutanea and acne shows no difference (P>0.05). 4) The illness integration in groups of hypertension and neurasthenia are higher than those of non-dryness syndrome groups (P<0.01). The comparison between the integrations of dryness syndrome groups of prurituscutanea and acne shows no difference with those of non-dryness syndrome groups (P<0.05). 5) The deficiency of both Ying and Yang in group of hypertension and dryness are the most related with total NDS integration (r=0.864, P<0.01); The canonical correlation coefficient showed that the NDS main and the accompanied symptoms with hypertension has a strong correlation, in which the dependent variable set of deficiency of both yin and yang, phlegm wet obstruct the lung from the independent variable group of spleen-stomach damp syndrome, the deficiencies syndrome of essence and blood of the liver and the kidney are the most relevant. The syndrome of depressed qi transforming into fire of neurasthenia is the most related with total NDS integration (r=0.692, P<0.01); The canonical correlation coefficient showed that the NDS main and the accompanied symptoms with hypertension has a strong correlation, in which the dependent variable set of yin deficiencies of the liver syndrome, the syndrome of qi depression transforming into fire from the independent variable group of the deficiencies syndrome of essence and blood of the liver and the kidney, yin deficiencies of the heart and kidney syndrome are the most relevant. The blood deficiency and wind dryness syndrome in group of prurituscutanea is the most related with total NDS integration (r=0.517, P<0.01); The canonical correlation coefficient showed that the NDS main and the accompanied symptoms with prurituscutanea has a strong correlation, in which the dependent variable set of the blood deficiency and wind dryness syndrome, damp-heat filled syndrome from the independent variable group of the lung and heart wind-fire pathogen syndrome, yin deficiencies of the spleen and stomach syndrome are the most relevant.The damp-heat syndrome of acne is the most related with total NDS integration (r=0.391, P<0.01); The canonical correlation coefficient showed that the NDS main and the accompanied symptoms with acne has a strong correlation, in which the dependent variable set of damp-heat syndrome, wind-heat syndrome from the independent variable group of the lung and heart wind-fire pathogen syndrome, Lung health skin pore opening dry permit are the most relevant.6) There is a strong correlation between the illness status of hypertension and syndromic state of NDS (f_i=0.51). The illness status of hypertension is also correlated with some accompanying syndromes (P<0.01), eg. deficiencies of essence and blood of the liver and the kidney syndrome (f_i=0.49); the lung and heart wind-fire pathogen syndrome (f_i=0.38), yin deficiencies of the heart and kidney syndrome (f_i=0.38). The corresponding index 0.31 (P<0.01) between the illness status of neurasthenia and syndromic state of NDS shows that there is a strong correlation between them. The corresponding index between the former and other accompanying syndromes are descending sorted as follows: deficiencies of essence and blood of the liver and the kidney syndrome (f_i=0.40), endogenous dampness syndrome (f_i=0.37), yin deficiencies of the heart and kidney syndrome (f_i=0.32), yin deficiencies of the lien and stomach syndrome (f_i=0.32), the lung and heart wind-fire pathogen syndrome (f_i=0.29). the illness status of prurituscutanea is only correlated with the lung and heart wind pathogen syndrome (f_i=0.30, P<0.01) but has no statistic significant with other syndromes (P>0.05). The integration of acne and its corresponding index with NDS show no statistic significant after testing. 7) The attack rates of Qi, Yang, Heart and Liver deficiency in case group are higher than those in control group (P<0.05). There is no difference in statistics on other deficiency syndromes. The attack rates of Yang deficiency (20.95%), heart deficiency (46.67%), lung deficiency (25.71%) and liver deficiency (40.48%) in heart system disease on blood vessel are higher than control group (P<0.05), especially on heart and liver deficiency. The attack rates of Qi deficiency (68.87%), heart deficiency (53.01%) and liver deficiency (43.37%) in heart system disease on mind are higher than control group. The attack rate of Yang deficiency (15.54%) is the only one which is higher than the control group in heart system disease on skin. 8) The attack rates of Qi, Xue, Ying and Yang deficiency syndrome and five internal organs of syndrome groups of coronary disease are higher than the non-dryness groups (P<0.01). The attack rates of Qi, Xue, Ying and Yang deficiency syndrome and five internal organs of syndrome groups of hypertension are higher than the non-dryness groups (P<0.01). The attack rates of Qi, Ying deficiency syndrome and heart deficiency, lung deficiency and liver deficiency syndrome groups of neurasthenia are higher than the non-dryness groups (P<0.01). The attack rates of Ying and Yang deficiency syndrome and heart deficiency, liver deficiency and kidney deficiency syndrome in groups of prurituscutanea are higher than the non-dryness groups (P<0.01). The attack rates of Qi deficiency, Blood deficiency, Ying deficiency syndrome and liver deficiency syndrome in groups of acne are higher than the non-dryness groups (P<0.01). 9) To compare the disease and syndrome group, disease and the sole-illness group, the sole-syndrome group and the health group: The physical constitution of the disease and syndrome group are the poorest than other groups. The sole-syndrome group listed on the second and the sole-illness group on third. The physical constitution of the non-illness and syndrome group is the best. Conclusion: 1) The northwest dryness syndrome, with yin deficiencies of the heart and kidney syndrome as a prominent feature, is one of risk factors and common accompanying status for heart system disease in Xinjiang Region. 2) There is a strong correlation among the status of heart system diseases and its syndromes. The correlation with the main and accompanying syndromes of NDS varies with the different features of each disease. 3) The group of heart system disease in Xinjiang, asthenia syndrome condition is serious than the control group, which is mainly characterized as Qi deficiency, Yang deficiency, heart deficiency and liver deficiency. 4) Yang deficiency physique is most obvious in the group of coronary disease. The outstanding performance of the five internal organs is heart deficiency, lung deficiency and liver deficiency. Lung deficiency is the special physique for the patients of coronary disease in Xinjiang. The physique of heart deficiency and liver deficiency is evident in hypertension, Qi deficiency is also represented. This is a different physique feature of hypertension patients in Xinjiang and inland. The physique of Qi deficiency, heart deficiency and liver deficiency is evident in neurasthenia; the physique of Qi deficiency, Yin deficiency and Yang deficiency is evident in prurituscutanea. As a whole, the physique in the group of acne is better than other groups. Deficiency of the kidney may be the potential pathological status of the patients of acne in Xinjiang. 5) NDS accentuates the deficiency symptoms of heart system disease. The prophylaxis and treatment of NDS will contribute to improve people’s health because it is the dominant manifestation of the sub-health status of people live in Xinjiang.