Study On The Relationship Between Hypertensive Patients Of Yin Deficiency And Yang Excess Type And Northwest Dryness Syndrome, Aquaporins

Objectives: To observe the changes of hypertensive patients of yin deficiency and yang excess type and Northwest Dryness Syndrome(NDS) in patients with serum AQP1, urine AQP2 concentration, and to explore the intrinsic link between AQP1, AQP2 and the pathogenesis of hypertension and NDS in Xinjiang area. Methods: A total of 180 cases were collected and divided into 6 groups. Group 1 was suffering from NDS in hypertensive patients of yin deficiency and yang excess type. Group 2 was suffering from NDS in hypertensive patients of non-yin deficiency and yang excess type. Group 3 was hypertensive patients of yin deficiency and yang excess type without the risk of NDS. Group 4 was hypertensive patients of non-yin deficiency and yang excess type without the risk of NDS. Group 5 was suffering from NDS healthy persons. Group 6 was healthy persons without the risk of NDS. Each group has 30 peoples. Collect blood and urine samples for all subjects. The concentration of serum AQP1 and urine AQP2 was detected by ELISA method, and the changes of serum AQP1 and urine AQP2 concentration were analyzed. Results : 1. Hypertension group compared with healthy group, AQP1 concentration decreased, AQP2 concentration increased, the differences were statistically significant(P<0.05). 2. Comparison of suffering from NDS hypertensive patients and hypertensive patients without the risk of NDS. The difference of reduction of AQP1 concentration was statistically significant(P<0.05), and there was no significant difference in AQP2 concentration. 3. Comparison of hypertensive patients of yin deficiency and yang excess type group and hypertensive patients of non-yin deficiency and yang excess type group. AQP1 concentration decreased, AQP2 concentration increased, the differences were statistically significant(P<0.05). 4. The resuits of pairwise comparison of serum AQP1 in 6 groups: Group 6 serum AQP1 was significantly higher than the other five groups, the difference was statistically significant(P<0.05). Group 4 were compared with group 1, group 2, group 3, group 5, the concentration of serum AQP1 was significantly higher, the difference was statistically significant(P<0.05). Group 1, group 2, group 3, the difference between the 5 groups was not statistically significant. 5. The resuits of pairwise comparison of urine AQP2 in 6 groups: Group 1, group 2, group 3, group 4, respectively compared with group 5 and group 6, urine AQP2 concentration is significantly higher, the difference is statistically significant(P<0.05). Group 1, group 2, group 3 contrast with each other, no significant difference in urinary AQP2 concentration. 6. AQP1 serum concentration and urinary AQP2 concentration was negatively correlated. Conciusions:1. The concentration of AQP1 decreased and the concentration of AQP2 increased in hypertension group, suggesting that AQP1 and AQP2 may be involved in the occurrence and development of hypertension. 2. In patients with hypertension, the concentration of AQP1 in the NDS group was lower than that in the non-NDS group. And in patients with healthy, the concentration of AQP1 in the NDS group was lower than that in the non-NDS group. the AQP1 concentration in the northwest dryness syndrome group was lower than that in the northwest group. These suggest that the low expression of AQP1 in human body is related to the occurrence of Northwest Dryness Syndrome. 3. Compared hypertensive patients of yin deficiency and yang excess type group with the hypertensive patients of non-yin deficiency and yang excess type group, the concentration of AQP1 decreased and the concentration of AQP2 increased, that a decrease in AQP1 concentration and AQP2 concentration increase may be the result of cause and aggravating factors of hypertensive patients of yin deficiency and yang excess type. The concentration of AQP2 in urine is closely related to hypertension, and it has little relationship with the NDS.