Kidney Circulation Treatment Of Adolescents With Polycystic Ovary Syndrome, Clinical And Experimental Research

Objective: The hypothesis of this study: the pathogenesis of the puberty polycystic ovary syndrome (PCOS) is the maladjustment of procreation axis named Kidney-TianGui- ChongRen meridians-womb. This disease is the syndrome of the root (Ben) deficiency and the branch (Biao) sthenia, In this case, the root is deficiency of kidney energy while the branch is blood stasis and phlegm stasis. The study adopts the method of disease combining syndrome and prescription combining syndrome. To observe the clinical effect and the experiment results with animal of Decoction for Strengthening Kidney and Eliminating Stasis.the decoction combining metformin to treat the puberty PCOS. And by this way, to study the characteristics, causes and pathogenesis of PCOS. And search a kind of more effective treatment method for the puberty PCOS. Methods: Choosing eighty SD big female rats of 23-day-born (clean grade) which meet the nation standard for animal experiment in medical science. Dividing the rats into 5 groups. One is the blank control group. The other four groups are induced the PCOS animal models with the dehydroepiandrosterone (DHEA), including the control group, the western medicine group, Chinese herbs group, the western medicine combining Chinese herbs group, the high density of Chinese herbs group and the western medicine combining with high density of Chinese herbs group. To observe the above five groups. According to the eligible standard, to divide the 12 sufferers into two groups by chance in clinical. One group simply cures with Decoction for Strengthening Kidney and Eliminating Stasis, while the other uses the decoction combining metformin. Conclusion: DHEA can induce the ideal PCOS animal model. The puberty PCOS has such three characters: the luteinizing hormone (LH) increase with the specific value of Follicle-Stimulating Hormone (LH/ FSH> 2.0), hyperandrogenism (the testosterone T increase) and hyperinsulinism. Deficiency of kidney energy, blood stasis and phlegm stasis are the important pathogeneses of PCOS. The puberty PCOS in treatment with Decoction for Strengthening Kidney and Eliminating the Stasis is effective. And the clinical treatment effect of the decoction combining metformin is better than pure Chinese herbal. Thereby it verifies the theory meaning and the application value of the above hypothesis.