Tonifying The Kidney,Strengthening The Spleen And Removing Blood Stasis Combined With Lifestyle Management In The Treatment Of PCOS With IR And Its Influence On Inflammatory Factors

Objective: To use Chinese medicine to nourish the kidney,invigorate the spleen to adjust the time and adjust the week combined with lifestyle management to treat Polycystic Ovarian Syndrome-Insulin Resistance(PCOS-IR)with phlegm and blood stasis,and to explore its therapeutic effect and its influence on inflammatory factors.Provide new ideas for clinical treatment.Methods: From February 2020 to January 2021,67 patients were diagnosed as insulin-resistant PCOS in the gynecological clinic of the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine.There are 67 patients spanided into three groups in this study by digital randomization,containing 22 cases in the simple traditional Chinese medicine group(instructor’s self-developed Xunshi Tiaozhou prescription),22 cases in the simple lifestyle management group,and 23 cases in the combined treatment group.All were treated for three consecutive menstrual cycles.Observe and compare the pre therapy and post-treatment of three groups with TCM syndrome scores,body mass index(BMI),waist-to-hip ratio(WHR),insulin resistance indicators(FPG,FINS,HOMA-IR),sex hormone indicators(T,LH,LH/FSH),Four indicators of blood lipids(TC,TG,HDL-C,LDL-C)and inflammatory factors(TNF-α,IL-6).The data obtained was analyzed statistically using SPSS25.0 software.Results:1.TCM syndrome score: After treatment,the three groups of TCM syndrome scores were all inferior to pre therapy,and the differences were all statistically significant(P<0.05);comparison between the groups,the combined treatment group had the best effect after treatment,followed by In the TCM weekly adjustment group,the lifestyle management group did not improve significantly,and the difference was statistically significant(P<0.05);2.BMI and WHR:(1)BMI and WHR after treatment in the lifestyle management group and the combined treatment group were lower than before,and the difference was statistically significant(P<0.05).The TCM weekly adjustment group did not improve significantly,and the difference in pre therapy and post-treatment was no statistical significance(P>0.05);(2)A comparison of the three teams indicates that existing a statistically significant difference in BMI with the combined treatment group and the lifestyle management group post-treatment(P<0.05).In terms of WHR,the two groups had the same curative effect,and the difference was not statistically significant.(P>0.05);After treatment,there was a statistically significant difference in BMI and WHR between the TCM weekly adjustment group and third group(P<0.05).And BMI was no statistically significant difference for the lifestyle management group(P>0.05),with statistically significant in WHR(P<0.05).3.Insulin resistance indicators:(1)FPG,FINS,HOMA-IR decreased pre therapy and post-treatment in the lifestyle management group with the third group,the difference was statistically significant(P<0.05);the traditional Chinese medicine week adjustment group FPG,FINS,HOMA-IR has no significant change from before treatment,and the difference is not statistically significant(P>0.05);(2)Compared between groups,there is no statistically significant difference in FPG and FINS between the lifestyle management group and the combined treatment group post-treatment(P>0.05)The difference in HOMA-IR was statistically significant(P<0.05);post-treatment,the TCM group of extents with FPG,FINS and HOMA-IR were statistically significant(P<0.05)with other two groups.4.Sex hormone indicators:(1)The levels of T,LH,LH/FSH in the three groups decreased compared with those before treatment,and the differences were statistically significant(P<0.05);(2)Compared between groups,the combined treatment group was compared with The T,LH/FSH levels of the other two groups decreased most significantly,and the differences were statistically significant(P<0.05),and the differences in LH levels were not statistically significant(P>0.05);post-treatment,For T,LH,and LH/FSH,it exists no statistically significant difference(P>0.05)with TCM weekly adjustment group and the lifestyle management group,and for the levels of T,LH/FSH of the combination treatment group,it exists a statistically significant difference(P<0.05),and the difference in LH levels was not statistically significant(P>0.05).5.Four indexes of blood lipids:(1)For the lifestyle management group and the combined treatment group,the difference of TC,LDL-C,TG was statistically significant(P < 0.05)with pre and post treatment,and the pre treatment of TCM group with TC,TG,LDL-C was no statistically significant(P>0.05),and the HDL-C levels of the three groups were not statistically significant pre and post treatment(P>0.05);(2)The combined treatment group and lifestyle management group showed no statistically significant difference(P>0.05)in TC,TG and LDL-C levels;post treatment with traditional Chinese medicine,the TCM group and the combined treatment group showed statistically significant differences in TC,TG,and LDL-C(P<0.05).For LDL-C and TC,the lifestyle management group existed a statistically significant difference(P<0.05),and there was no statistically significant difference in TG(P>0.05).6.Inflammatory factor indicators:(1)In contradistinction to pre treatment,it existed distinct downward trend for TNF-α and IL-6 in the three groups,and the differences existed statistically significant(P<0.05);(2)In contradistinction to post treatment with three groups,,the combined treatment group TNF-α and IL-6decreased most significantly compared with the other two groups,and the difference was statistically significant(P<0.05);after treatment,there was no statistical difference in the reduction of TNF-α and IL-6 between the TCM weekly adjustment group and the lifestyle management group Academic significance(P>0.05).Conclusion:1.Compared with simple lifestyle management or simple traditional Chinese medicine to adjust the week,traditional Chinese medicine can reduce BMI,WHR,improve insulin resistance and blood lipid metabolism.It can also improve PCOS with phlegm and blood stasis.-IR patients’ TCM syndrome manifestations,especially in improving menstrual disorders,regulating and assisting pregnancy,this provides new and better treatment ideas for better clinical treatment of PCOS-IR.2.Lifestyle management,as a first-line treatment for PCOS,is more effective than traditional Chinese medicine for reducing BMI,WHR,improving insulin resistance and blood lipid metabolism;it has the same effect as traditional Chinese medicine for adjusting sex hormone levels and reducing inflammatory factors.At the same time,compared with simple lifestyle management,the advantage of TCM weekly adjustment method is reflected in improving patients’ TCM syndromes.3.TCM time-adjustment combined with lifestyle management can significantly reduce the level of inflammatory factors in the patient’s body,improve the patient’s chronic inflammatory state,and the efficacy is better than simple lifestyle management and traditional Chinese medicine week-adjustment.