The Research On Optimized Solution Of Treating The HMG By The Method Of Reducing Phlegm And Scatteirng Stasis As The Core And Synthetically Conditioning Function Of Organs

Objective: Optimized solution of treating the HMG by the method of reducingphlegm and Scattering stasis as the core and synthetically conditioning function of organs.Prove the effection,reliable,secure,and the feasibility of the solution scientifically,to form astandardized,easy,broad consensus diagnosis and treatment program due to HGM.Methods:First,researched literature and evaluate the quality of clinical trials of treating HMG byTCM.then mine the law of TCM and drug in treating HMG.and sumed up our own clinicalexperience,then proposed our treatment program of HMG.Second,after several rounds ofdiscussion by experts,the optimized program formatted gradually.third, demonstrate theeffectiveness and security of the solution and Kaiyu Sanjie Particles by the method ofmultiple centers,random,double-blind,parallel control.The syudy was carried out in7research center at the same time.Take8weeks as a treatment,then tell the patient to visit usat the time of8weeks after treating,the main outcome measure include the pain,thelumps,the systemic symptoms and the ultrasongraphic.And use the evaluation of qualitylife as the objective indicator at ehe first time.Result:1.Form the dialectical thinking ofHMG:take Qi stagnation,phlegm gather for a total of etiology and pathogenesis,take liverdepression and spleen,liver and kidney deficiency,disorder of Chong and Ren as the basedlesions.at the same time, the main treatment principles is formed: take stasising phlegm asthe main treatment rule of HMG.2.The result of clinical studies:(1)There were no statisticalsignificance difference between the two groups of Kaiyu Sanjie Particles and placebo inthe aspect of basic condition(P>0.05),so these two groups are comparable.(2)There aresignificant difference between the two groups on pain score,pain grade,tendernessscore,total pain score at the time of treatment and follow-up,and the cores of experimentalgroup are all lower than the placebo group (P<0.05).(3)The difference are also significant between the two groups on mass distribution,tumor size,total mass score at the time oftreatment. There are also significant difference between the two groups not only on theaspect of all of the above,but also on mass texture at the time of follow-up,andexperimental group is superior to placebo.(4) There are significant difference between thetwo groups on the score of the main symptoms at the time of treatment and follow-up,andthe cores of experimental group are all lower than the placebo group (P<0.05).particularlyon the aspects of easing xiong xie fullness,irritability and abdominal distension.Howeverthe efficacy duration soon,at the time of follow-up,it has effection in relieving abdominalfullness.(5)For the main symptoms:the total effective rate of treatment group is63.48%.For the systemic syptoms: it is79.13%.And for the disease: after8weeks,it is70%.At the time of8weeks after treatment, the total effective rate of treatment group is72.17%.The efficacy of all of the above, the difference between the two groups issignificant (P<0.05).(6)The difference are not significant between the three type ofsyndrome on mass score,pain score, the total effective rate at the time of treatment(P>0.05).(7) There are significant difference between the two groups on the score of ultrasound atthe time of treatment,and the cores of experimental group are lower than the placebogroup,and the reducment of score is more.(P<0.05).(8)There are four cases of adversevents in the experimental goup,and that in the placebo group is two cases,the incidence ofthat in both of the two groups are1.67%,and the difference of that is not significantbetween the two groups(P>0.05).(9)The result of grass-roots promotion:On the pain, thetotal effective rate is72.86%.On the mass,it is54.29%.On the main symptoms,it is74.29%.On the systemic symptoms,it is74.29%.And on the disease,it is75.71%.Conclusion:optimized solution of treating the HMG by the method of reducingphlegm and Scattering stasis as the core and synthetically conditioning function of organsform at last, and it is easy,broad consensus,and can be disseminated easily.The effectiverecipe of treating HMG is founded.and and Kaiyu Sanjie Particles have better efficacy thanplacebo on reducing breast pain,alleviating breast mass and improving syatemic symptoms,ultrasound evaluation, and it has balanced effect on the three type of syndrome,but has notoxicity.ao it is suitable for clinical use.Through the promotion of grass-roots,furtherverifying it's effection,security,operability.