Research On The Prescription And Syndrome Of Guizhi Decoction By Data Mining

Objective:《GUIZHI DECOCTION》is the first prescription in "Treatise on Cold Pathogenic and Miscellaneous Diseases", which is the general prescription for harmonizing yingfen and weifen, qi and blood, yin-yang. Although it only consists of five herbal medicines, no other prescription can be comparable in the aspects of wide range of application and variety of categorized formula. The prescription and syndrome of GUIZHI DECOCTION is namely its clinical indications and pathogenesis, which has been researched widely in the literatures of past dynasties. In this thesis, based on the experience of herbalist doctors of past dynasties, it uses the data mining technology to research the prescription and syndrome of GUIZHI DECOCTION, which aims to unveil the multi indications and multi functions, and the application rule of extending use, the rule of prescription modification with syndrome. Mining the diagnosis standard of GUIZHI DECOCTION from application from GUIZHI DECOCTION and its modification can make the prescription and syndrome of GUIZHI DECOCTION standardization, objective so as to guide clinic application.Methods:The research data in this thesis come from 1) "Treatise on Cold Pathogenic and Miscellaneous Diseases "(33 cases of GZT and its categorized formula, related to 62 items of original text); 2) "Prescription Dictionary"(93 prescriptions of GZT and its modification); 3) Modern clinical application(421 clinical cases treated by GZT and its modification);4) Relevant medical literatures (39 medical literatures, covering 92 clinical cases). In our research, the data is processed by standardization first, and the databases of symptom, prescription, treatment with medicine are built respectively, the prescription, symptom and treatment with medicine in above three types of literatures are made statistic respectively. Then, reference research method is used to research the prescription and symptom of《GUIZHI DECOCTION》,and factor analysis is used to analyze for above three types of literature, which is to reveal the pathogenesis,varied syndrome and the law of herbal synergy of GUIZHI DECOCTION and its modifying prescription. Besides, the bi-direction association rule is used to analyze the association relationship of disease -prescription,syndrome-prescription,disease-the rate of GuiZhi Shaoyao dosage in above three types of literature, which is to reveal the relationship among the disease-syndrome-prescription-herbal medicine for GUIZHI DECOCTION and its modifying prescription. In our research, the concept of the family categorized formule is introduced so as to reveal the relationship among GUIZHI DECOCTION and other categorized formula。Result:1 Factor analysis results on symptom from three kinds of literature reflect that the GUIZHI DECOCTION has following features on syndrome:exogenous disease of disharmony between nutrient qi and defensive qi, devitalization of heart yang, body pantalgia, syndrome of incoordination between spleen and stomach, syndrome of qi rushing upward, where factor analysis results of Prescription Dictionary and Modern clinical application reflect the syndrome features on disharmony between nutrient qi and defensive qi, deficiency of both yin and yang.2 The factor analysis results on treatment with medicine from three kinds of literature are overlapped in certain degree, which reflects the medicine modifying rules of GUIZHI DECOCTION categorized formula, such as guizhi decoction, guizhi houpu xingzi decoction, guizhi longgu muli decoction, danggui sini decoction, linggui shugan decoction, guizhi gegen decoction, guizhi fuzi decoction, huangqi jianzhong decoction,guizhi xinjia decoction. Beisdes, the factor analysis results on treatment with medicine from Prescription Dictionary and Modern clinical application also reflects the herbal synergy rules of caihu guizhi decoction, guizhi qianghuo decoction, guizhi xinjia decoction, guizhi gancao decoction etc.3 The association analysis on disease-prescription from three kinds of literature show the GUIZHI DECOCTION has close association with exogenous disease of fever, failure of keeping essence. Xiao jianzhong decoction, huangqi jianzhong decoction has close association with consumptive diseas and abdominal pain. The results from Modern clinical application also indicate that GUIZHI DECOCTION has close association with dermatosis and body pantalgia.4 Based on the association analysis on syndrome-prescription from three kinds of literature, the principal syndrome of GUIZHI DECOCTION inferred from the correlation degree is floating and moderate pulse, sweating. The complication syndrome is fever, aversion to wind, aversion to cold, headache, thin and white fur, natural stool and pee. According to the correlation degree on syndrome-prescription from modern literatures, the principal syndrome and the complication syndrome can inferred for modifying prescription of GZT, such as caihu guizhi decoction, danggui sini decoction, guizhi fuzi decoction, guizhi mahuang decoction etc.5 The association analysis on rate of Guizhi Shaoyao dosage reveals that the frequency of this rate with 1:1 is high in "Treatise on Cold Pathogenic and Miscellaneous Diseases" with 61%; the frequency of this rate with 1:0 is high in "Prescription Dictionary" with 33%, and for modern clinical application, the this rate with high frequency is 1:1,1:0,1:2,5:3. The rate with 1:1,1:0,1:2,5:3, is mainly used for exogenous disease of superficies syndrome and body pantalgia, devitalization of heart yang and syndrome of qi rushing upward, consumptive diseas and abdominal pain, syndrome of qi rushing upward respectively.6 The association analysis on couplet medicines of three kinds of literature cues us that the two herbal synergy is very popular in ancient literatures, but in modern clinical application, due to herbal modifying in prescription, the hinted couplet medicines is the two herbal after modifying.Conclusion:Based on above research, some rules are summed up for GUIZHI DECOCTION and its modifying prescription, such as the relationship between prescription and syndrome, effect and quantity, effect and composition. The principal prescription and syndrome of GUIZHI DECOCTION and its modifying prescription can be concluded as follows:1 The syndrome of GUIZHI DECOCTION original prescription has four aspects: (1) Taiyang superficies syndrome (2)syndrome of incoordination between spleen and stomach with superficies syndrome (3)disharmony between nutrient qi and defensive qi without external cause (4)hyperemesis gravidarum. The pathogenesis of GZT is disharmony between nutrient qi and defensive qi. Besides, the applicable constitution feature of GZT is also summed up.2 The syndrome of modifying prescription of GUIZHI DECOCTION can be grouped into 7 types, they are (1)exogenous disease of fever, (2)muscle spasm, (3) body pantalgia, (4) abdominal pain, (5) syndrome of qi rushing upward, (6) devitalization of heart yang, (7) failure of keeping essence.3 The rule of relationship between component and effect of GZT:The original prescription of GZT is based on the two prescription of guizhi gancao decoction and shaoyao gancao decoction. By the factor analysis results, herbal modifying rule of 20 prescriptions of GZT and their principal symptom are concluded, and their family relationship with original prescription of GZT is also analyzed.4 The rule of relationship between effect and quantity of GZT and its modifying prescription is as follows:the rate of Guizhi Shaoyao dosage with 1:1 is mainly from original prescription or cognation of GZT, which has the indication of expelling pathogens from both interior and superficies, harmonizing yingfen and weifen. The rate of Guizhi Shaoyao dosage with 1:0 is mostly the far family of GZT, which has the indication of warmly invigorating heart yang, activating qi for lowering adverse qi. The rate of Guizhi Shaoyao dosage with 1:2 is mostly the modifying family of GZT, which has the indication of warming yang and removing obstruction in collaterals, relieving spasm and relieving pain. The rate of Guizhi Shaoyao dosage with 5:3 has the indication of expelling pathogenic factors from muscles and warming yang, activating qi for lowering adverse qi.Finally, At the end, the harmonizing effect, the decoction method and modern pharmacody of GZT are discussed. Meanwhile, the advantage and disadvantage of data mining technology used in this thesis are discussed, and research in the future is prospected.Innovation:The bi-direction association rule and factor analysis are used to research the prescription and syndrome of classical prescription at same time. Besides, the correlation degree of syndrome and prescription is used to infer the principal syndrome and complication syndrome of prescription, which makes the standard of the principal syndrome and complication syndrome of prescription more objective. The family cluster relation is used to analyze GZT and its categorized formula so as to makes the research visualization, systematic.