The Comparative Study Between Diagnostic Imaging And Pathology In Congenital Heart Defects Associated With Severe Pulmonary Hypertension In Young Children

1.The Quantitative Analysis of the Pulmonary Arteries in Biopsy Tissues in Young Children with Severe Pulmonary Hypertension Caused by Congenital Heart Defects Compared with that in Normal Autopsy TissuesObjective: The biopsy lung tissues from young children with severe pulmonary hypertension caused by congenital heart defects and the autopsy lung tissues from infants and young children died of non-cardiovascular diseases were quantitatively analyzed, so as to distinguish the arteriopathy from normally developing arteries.Methods: Lung biopsies were taken in the corrective operations in 38 young children suffered from left to right shunt congenital heart defects associated with severe pulmonary hypertension. Autopsy specimens were obtained from 10 children died of non-cardiovascular diseases. The tissue was fixed with buffered formalin, routinely prepared by impregnated in wax. Sections were stained by hematoxylin-eosin, Weigert's elastic stain counter-stained by van Gieson's method. Biopsies were graded according to the Heath-Edwards classification. The diameters of internal and external elastic lamina, and the area inside internal and external elastic lamina were measured by a computed image processor. The area of the section was also measured (mm~2), muscular arteries within...