Clinical Observation On Shugan Xiaolu Pills In The Treatment Of Granulomatous Lobular Mastitis Of Liver Depression And Phlegm Coagulation Type In The Mass Stag

Objective: By observing the difference of TCM syndrome score,mass size,pain degree and effective rate of Shuganxiaoluowan and Methylprednisolone Tablets in the treatment of granulomatous lobular mastitis before and after the treatment,the exact clinical effect of Shuganxiaoluowan in the treatment of granulomatous lobular mastitis at the mass stage of liver-stagnation spittoon type was discussed.Methods :According to the inclusion criteria,60 patients who attended our outpatient clinic from December 2021 to December 2022(granulomatous mastitis with liver depression and phlegm coagulation type mass stage)were selected.According to the random number table,they were equally assigned to two groups of 30 cases each: the Shuganxiaoluowan group(treatment group)and the methylprednisolone group(control group).The treatment group was given the soup of Liver Dredging and Scrofula Pill for internal use,and the control group was given the tablets of methylprednisolone for internal use.Both groups were treated with 4 weeks as a course of treatment,and a total of 3courses of treatment were observed for 12 weeks.The differences in mass size,pain level,TCM symptoms score,efficiency rate and adverse reactions between the two groups were compared before and after the treatment.Results :A total of 60 patients with granulomatous lobular mastitis at the mass stage of liver-depression spittoon type were included in this study,with 30 patients in each treatment group(Shuganxiaoluowan group)and control group(methylprednone group).Before treatment,there were no statistical differences in age,laboratory test results(leukocyte count,neutrophil percentage,C-reactive protein,interleukin-6,serum prolactin,T lymphocyte subsets),mass size,TCM syndrome score and pain score between the two groups,and the two groups were comparable(P > 0.05).After treatment,the tumor size,TCM syndrome score and pain score of the two groups were improved compared with that before treatment.After treatment,there were statistical differences between the two groups in reducing tumor size and TCM syndrome score.The treatment group was better than the control group,but there was no statistical difference in reducing pain score.After treatment,the effective rate of treatment group was higher than that of control group,and the occurrence of adverse drug reactions was less than that of control group.Conclusion:(1)Both Shuganxiaoluowan and Methylprednisolone Tablets have definite efficacy in granulomatous lobular mastitis with liver stagnation and phlegm coagulation;(2)Compared with Methylprednisolone Tablets,Shuganxiaoluowan has more significant clinical efficacy,especially in reducing masses and improving concurrent symptoms.In terms of pain relief,there is no difference in the effect of methylprednisolone Tablets and Shuganxiaoluowan;(3)Shuganxiaoluowan has less adverse effects and is safe.