To Summarize The Medication Rules Of Professor Yang Yi In The Treatment Of Granulomatous Lobular Mastitis In Mass Stage Based On Data Mining And Observe Its Clinical Efficacy

Objective:To explore the medication rules of professor Yang Yi in the treatment of Granulomatous lobular mastitis(GLM)in mass stage by data mining method,summarize his academic thought,summarize the core prescription and apply it in clinical practice.The clinical efficacy of professor Yang Yi’s core prescription(Qingre Sanjie prescription)was observed to verify the unique advantages of traditional Chinese medicine in the treatment of this disease.Methods:This project includes two parts: data mining and clinical research.The data mining part collected the traditional Chinese medicine prescriptions prescribed by professor Yang Yi for GLM patients in the mass stage from November 2019 to December 2021,established a database,and conducted data mining on drug frequency,drug properties,drug classes,prescription rules,core prescriptions and other aspects after standardizing drug names.Combined with objective data and clinical experience,the medication rules of professor Yang Yi in the treatment of GLM mass stage were summarized,and the core prescriptions were summarized and applied in clinical practice.In the clinical research part,the core prescription obtained by data mining was named Qingre Sanjie Decoction.Then 60 GLM patients with liver meridian stagnation heat syndrome at the mass stage from January 2022 to September 2022 were screened and randomly divided into control group(hormone therapy)and treatment group(hormone therapy + Qingre Sanjie decoction).Before treatment,4 weeks after treatment and 6 weeks after treatment as the observation nodes,the differences in breast mass size,pain score,skin color score,clinical syndrome total score,breast shape aesthetic degree,recurrence rate and incidence of adverse reactions between the two groups were observed and statistically analyzed and discussed.Results:Data mining:142 prescriptions were included in this study,involving 91herbs,and 20 of them were used more than 60 times,including scutellaria baicalensis,Lonicerae japonica,dandelion,Bupleuri,Prunella vulgaris,red peony root,Trichosanthes sinensis,Radix sinensis,Angelica sinensis,Platycodon radix,Dahurica dahurica,scrophularia sinensis,Astragalus membranaceus,anemarrhenae rhizoma,Gardenia jasminoides,Coicis seed,white flower hedtis,celecoxoides and Atractylodes.From the perspective of drug property and taste,cold and warm drugs and bitter,sweet and spicy drugs were the main ones.From the perspective of drug meridians,most of them were attributed to lung,liver,stomach and spleen meridians.The effects of drugs were mainly clearing heat,tonifying deficiency and eliminating phlegm.According to the analysis of association rules,the common drug combinations of professor Yang Yi in the treatment of GLM mass stage were bupleurum-scutellariae,honeysuckle-scutellariae,dandelion-scutellariae,Bupleurum-honeysuckle-scutellariae,dandeline-honeysuckle-scutellariae.According to the cluster analysis,Professor杨毅’s core prescriptions were as follows:Scutellaria baicalensis,Lonicerae japonica,dandelion,Bupleuri,red peony,Tianpollen,Angelica dahurica,Radix platycodon,anemarrhena asarum,Gardenia fructus,Coicis seed,Hedyotis alba,saponiae saponiae,Scrophularia vulgaris,Prunella vulgaris,Radix astragali,citrus peel,Atractylodes atractylodes.Clinical study: A total of 56 patients completed the study according to the protocol,with 28 cases in the treatment group and 28 cases in the control group.(1)There were no significant differences in age and onset days between the two groups(P > 0.05).(2)There were no significant differences in breast tumor size,pain score,skin color score,and total clinical syndrome score between the two groups before treatment(P > 0.05).There were significant differences in breast mass size,pain score,skin color score,total clinical syndrome score and total effective rate between the two groups after 4 weeks and 6 weeks of treatment(P < 0.05).There were significant differences in the recurrence rate and the incidence of adverse reactions between the two groups before and after treatment(P < 0.05).There was no significant difference in breast appearance between the two groups before and after treatment(P > 0.05).(3)In terms of breast mass size and pain score,there were statistically significant differences between the two groups before treatment,4 weeks and6 weeks after treatment(P < 0.05).In terms of skin color score and total clinical syndrome score,there were statistically significant differences between the two groups before and after 4 weeks of treatment,before and after6 weeks of treatment(P < 0.05).There was no significant difference between the two groups after 4 weeks and 6 weeks of treatment(P > 0.05).Conclusions:1.Professor Yang Yi believed that the pathogenesis of GLM mass stage was mainly heat stagnation of liver and stomach,heat toxin accumulation and deficiency of Qi and Yin.In treatment,attention should be paid to clearing heat and detoxifying,qi and Yin nourishing,phlegm and dispersing condensation,and both specimens should be taken into account.2.For GLM syndrome of liver meridian stagnation of heat in mass stage,both hormone therapy alone and Qingre Sanjie prescription combined with hormone therapy can reduce the scope of the mass and relieve the symptoms of redness,swelling,heat and pain,which are effective treatment methods.3.Professor Yang Yi’s core prescription(Qingre Sanjie Prescription)can significantly improve the size of breast lump,pain degree and skin redness in patients with GLM lump-stage liver heat stagnation syndrome,and can also reduce the recurrence rate and reduce adverse reactions.It is an effective prescription worthy of more promotion and inheritance.