| Objective: To observe the clinical effect of Yinqi Sanhuang Jiedu Decoction on patients with dampness-heat syndrome of liver depression and spleen deficiency in compensatory hepatitis B related cirrhosis,to understand and accumulate the efficacy and experience of Yinqi Sanhuang Jiedu decoction in the treatment of such diseases,and to provide evidence for the treatment of cirrhosis from the spleen.Methods: The randomized controlled study method was adopted in this study.34 patients in the control group and the treatment group who met the admission criteria were included in the hepatology outpatient Department of Affiliated Hospital of Chengdu University of TCM.The control group was given Entecavir,and the treatment group Yinqi Sanhuang Jiedu Decoction combined with Entecavir.The treatment period was about 52 w,and all indexes were recorded before treatment,26 w and 52 w,respectively.During the period,2 patients in the control group had protective discontinuation and 3 patients in the treatment group had shedding.The data were tested and analyzed by SPSS 25.0.Result: 1)At the baseline level of enrolled patients,gender,age,total score of TCM syndromes,PLT,ALT,AST,GGT,ALP,ALB,TBIL,AFP,portal vein diameter,spleen thickness diameter,LSM,FIB-4,APRI,GPR,S index and other indicators were compared between the control group and the treatment group,all P > 0.05.It is suggested that the baseline level of the two groups of patients is basically balanced and comparable.2)In the aspect of TCM syndrome score,the comparison of total syndromes within groups and between groups showed P < 0.05.Fatigue,dry mouth,bitter mouth,loss of appetite and yellow urine were compared between groups and groups,all P <0.05.Abdominal distension,tightness and nausea were compared in the group(P <0.05),and the treatment group was compared with the control group(P < 0.05)at 26 w.Comparison of borborygmus in group,P < 0.05;The treatment group was compared with the control group at 52 w,P < 0.05;Compared with the control group before treatment and 52 w treatment,the yellow staining of skin and eye in the treatment group was P < 0.05.These results indicated that the clinical manifestations of the two groups were improved to varying degrees.3)In terms of serological and other indexes,the comparison of PLT,AST,TBIL,spleen thickness and LSM,FIB-4 and APRI groups in the treatment group was P <0.05,indicating that patients in the treatment group had been effectively improved after 52 w of treatment compared with before treatment.After 52 w of treatment,P <0.05 was compared between groups,indicating that the improvement degree of patients in the treatment group was more obvious than that in the control group.P <0.05 in the treatment group,indicating that AFP in the treatment group was effectively improved at 52 w.P < 0.05 showed that AFP in treatment group was better than that in control group.Compared with before treatment,the GPR and S index in the treatment group showed that P < 0.05,indicating that the GPR and S index in the treatment group were significantly improved at 52 w compared with before treatment.4)In the course of this study,the incidence of loose stool in the treatment group was higher than that in the control group(P < 0.05),and no special discomfort occurred in the rest.Conclusion: Yinqi Sanhuang Jiedu Decoction can significantly reduce the clinical symptoms of patients with dampness-heat syndrome of liver qi and spleen deficiency in hepatitis B related cirrhosis during the compensatory period,improve AST,TBIL,LSM,FIB-4,APRI and other indicators,and has certain functions of protecting liver and reducing yellow and improving fibrosis. |
