Observation On The Curative Effect Of Qingfeihuatan Yin On The Treatment Of Community Acquired Pneumonia With Phlegm-heat Obstructing Lung Syndrome

Objective: To observe the clinical efficacy of Qingfei Huatan Yin in the treatment of adult community acquired pneumonia(phlegm-heat accumulation lung type),and to evaluate its safety,so as to provide clinical data support for the clinical application of this formula.Methods: A total of 88 patients who were diagnosed with CAP and met the inclusion criteria in the Department of Pulmonary Diseases,Ningxia Hospital of Traditional Chinese Medicine & Academy of Traditional Chinese Medicine from December 2021 to December2022 were collected.All the 88 patients enrolled were freely divided into into observation group and control group,which group had 44 cases.The control group was treated with conventional antibacterial and symptomatic treatment according to the guidelines,and another group was treated with Qingfei Huatan Yin on the basis of the control group western medicine.After 3 days of observation and before discharge,we will observe and analysis the TCM syndrome score,white blood cell count(WBC),neutrophil percentage(NE%),C-reactive protein(CRP),procalcitonin(PCT),plasma D-dimer(D-D),chest CT absorption,length of hospital stay,and safety indicators(general vital signs,blood routine,urine routine,stool routine,electrocardiogram,liver function,and renal function).Results:(1)Study completion: There are 88 patients who were diagnosed CAP in this clinical observation,and 5 patients dropped out of the control group and 4 patients in the observation group during the observation period.Finally,79 patients completed the treatment.(2)There were no significant differences in gender composition,age distribution,pathogen results,and types of antibiotics used between the two groups in baseline data(P >0.05),which were comparable.(3)Efficacy evaluation of TCM syndromes: the total effective rate of the control group was 82.05%,and the total effective rate of the observation group was 95%.The difference of total effective rate between the two groups(P < 0.01)was statistically significant,and the observation group was higher than the control group.(4)Comparison of TCM symptom scores: there was no statistical significance in TCM symptom scores between the two groups before treatment(P > 0.05),which was comparable,After 3 days of treatment and before discharge,the total score of TCM syndromes decreased significantly compared with that before treatment(P < 0.01),and the observation group was better than the control group(P < 0.05).(5)Laboratory indicators: there were not difference between the two groups in WBC,NE%,CRP,PCT and D-D levels before treatment(P > 0.05).After 3 days of treatment,WBC,NE% and PCT of patients were obviously decreased in both group(P < 0.05),but there was no difference between the two groups(P > 0.05).The WBC and NE% of the two groups before discharge were significantly lower than those on admission(P < 0.01),There are differences between the two groups(P < 0.05).CRP values decreased after 3 days of treatment(P < 0.05),observation group decreased more than the control group(P < 0.05).The D-D of the two groups before discharge was significantly lower than that on admission(P < 0.01),both groups declined to the same extent(P > 0.05).(6)Chest CT absorption: The chest CT of patients in the two groups was absorbed compared with that on admission,Observation group infection focal absorption is better than the control group(P < 0.05).(7)The length of hospital stay: Two groups of hospitalization days there’s a difference,observation group hospitalization days less than the control group(P < 0.05).(8)Safety evaluation: Patients in the two groups had stable vital signs,routine hematuria and stool,liver function,kidney function,electrocardiogram and other related safety indicators,and there were no obvious abnormalities in the course of treatment.Conclusions:Qingfeihuatan Yin with conventional therapy CAP(thermal aggregates lung phlegm)curative effect.which can significantly improve the effective rate and integral of TCM symptoms,reduce inflammation indicators,promote the absorption of chest CT infection and shorten the length of hospital stay,and there is no serious adverse reaction in the course of clinical application.It can be used in clinical syndrome differentiation and has a certain promotion and further research value.