Effect Of Gubenyishen Decoction On Renal Function In Patients With CKD Stage 4-5 Non-dialysis With Spleen Kidney Qi Deficiency And Blood Stasis And Damp Heat Syndrome

Objective:To observe the effect of Gubenyishen Decoction on renal function in patients with CKD stage 4-5 non-dialysis with spleen kidney qi deficiency and blood stasis and damp heat syndrome,and to evaluate its clinical efficacy.Methods:A total of 70 outpatients and inpatients with CKD stage 4-5 non-dialysis with spleen kidney qi deficiency and blood stasis and damp heat syndrome were selected fromNovember 2021 to December 2022,meeting the inclusion criteria,and were randomly divided into a control group and a treatment group.The control group was given conventional treatment,and the treatment group given conventional treatment and Gubenyishen Decoction.After 12 weeks of treatment,to assess independently before and after treatment about the scores of TCM syndromes,the total curative effect of TCM syndromes,Serum creatinine（Scr）,Blood urea nitrogen（BUN）,Glomerular filtration rate（e GFR）,Cystinase inhibitor C（Cys-C）,Urinary albumin/creatinine ratio（ACR）,24h urinary protein quantity（UTP）,β₂microglobulin（β₂-MG）and Urinary N-acetyl-glucosaminidase（UNAG）,Blood uric acid（SUA）,Fasting plasma glucose（FPG）,Total cholesterol（TC）,Triglyceride（TG）,and hemoglobin（Hb）etc.Results:1.In the above 70 patients,the patients with spleen and kidney qi deficiency combined with damp heat syndrome accounted for 41.79%,the syndrome of blood stasis accounted for37.31%,and the syndrome of dampness-blood stasis accounted for 20.90%.2.TCM syndrome scores of both groups decreased after treatment.After 4 weeks of treatment,the syndrome of spleen and kidney qi deficiency combined with blood stasis and damp heat syndrome decreased significantly in 2 groups compared with before treatment（P<0.05）.After 8 weeks of treatment,the combined syndrome scores in the treatment group and the control group were lower than before（P<0.05）,and the spleen and kidney qi deficiency combined with blood stasis in the treatment group was lower than that in the control group（P<0.05）.After 12 weeks of treatment,the syndrome scores of the treatment group and the control group were lower than before（P<0.05）,and the three syndrome scores of the treatment group were lower than that of the control group（P<0.05）.3.The total effective rate of TCM syndrome was significantly different between the two groups,which was 91.18%in the treatment group and 69.70%in the control group（P<0.05）.4.After the end of the treatment cycle the lever of Scr,BUN,Cys-C,ACR,UTP,β₂-MG,UNAG were decreased,e GFR went up in two groups.In addtion,the lever of ACR,UTP and UNAG were decreased in two groups（P<0.05）.BUN was decreased statistically in treatment group（P<0.05）.After the end of the treatment cycle,the differences of ACR and UNAG were statistically significant,and the treatment group was better than the control group.（P<0.05）.5.After the end of the treatment cycle lever of SUA and TC indexes in the two groups were decreased,HB was increased,FPG and TG were not significantly changed,and SUA decreased in the two groups,and TC decreased in the treatment group statistically significant（P<0.05）.In addition,after the end of the treatment cycle,there was no significant change in various indicators between the groups,and the difference was not statistically significant.Conclusions:Gubenyishen Decoction can reduce the TCM syndrome score of patients with CKD stage 4-5 non-dialysis with spleen kidney qi deficiency and blood stasis and damp heat syndrome,improve indicators of kidney function and indicators related to risk factors,and clinical effect is significant and safe.