A Meta-analysis Of Exposure To Perinatal Risk Factors For Congenital Microtia

Objective:This paper conducted a meta-analysis of potential risk factors affecting the pregnancy and perinatal period of isolated microtia,so as to explore possible risk factors,so as to provide reference for clinical prevention of congenital microtia.Method:Literature retrieval was conducted in English and Chinese databases(including Pub Med,The Cochrane Library,Embase database,CNKI,VIP,Wanfang Medical Network).The literature retrieval time was from the establishment of the database to February 2023.Key words: "microtia" "Anotia" "ear abnormalities" "cryptotia" "Congenital Microtias" "risk factors" "exposure","microtia","ear deformity","risk factors","exposure",to search for related articles on the risk factors of congenital microtia exposure during pregnancy and childbirth.The selected articles should be retrospective cohort studies and case-control studies,and the risk factors mainly include: Maternal body mass index,respiratory tract infections during pregnancy,passive smoking during pregnancy,alcohol intake during pregnancy,folic acid intake during pregnancy,use of progesterone and other hormone drugs during pregnancy,reproductive system infections during pregnancy,gestational diabetes,gestational hypertension,ethnicity of pregnant women,exposure to occupational factors of pregnant women,reproductive history of pregnant women,abnormal pregnancy history of pregnant women,use of pregnancy protection drugs,Maternal age of childbirth,maternal education level,fetal sex,etc.Results:A total of 18 literatures were included,including 15 English literatures and 3 Chinese literatures.A total of 49353 cases were included in the experimental group and the control group.The results show that: Maternal body mass index(P= 0.0003,I 2=0%),gestational diabetes(P <0.00001,I 2=0%),age of delivery(P=0.007,I 2=63%),maternal education(P <0.00001,I 2=0%),race(P <0.00001,I 2=0%),maternal fertility history(P <0.00001,I 2=0%),abnormal pregnancy history(P <0.00001,I 2=79%),multiple pregnancy history(P =0.003,I 2=30%),pregnancy disease(P <0.00001,I 2=0%),indoor decoration environment(P <0.00001,I 2=53%),exposure to related occupational risk factors(P <0.00001,I 2=20%),passive smoking(P <0.00001,I 2=67%),intakes of progesterone hormones in the perinatal period(P =0.0002,I 2=0%),use of antibiotics in early pregnancy(P =0.006,I 2=0%),fetal preservation treatment during pregnancy(P =0.0006,I 2=20%),these related factors are all risk factors for congenital microtia.Folic acid intake(P <0.00001,I 2=93%)and long-term tea drinking habit(P <0.00001,I 2=0%)were protective factors for congenital microtia.Conclusion:In this paper,a meta-analysis was conducted on 18 Chinese and English literatures,and data integration was conducted for 26 risk factors.By analyzing these related factors,it can provide reference for clinical guidance to prevent the occurrence of congenital microtia.