| Objective:This subject analyzes and observes the clinical efficacy and safety of Fumin Qingbi Granules in the treatment of patients with Bibi(psoriatic arthritis)damp-heat obstruction syndrome,so as to make a preliminary judgment on the new idea of traditional Chinese medicine treatment of Bibi damp-heat obstruction syndrome.Methods:A randomized controlled design was adopted in the study.Sixty patients who met the inclusion criteria and did not meet the exclusion criteria in the outpatient department of rheumatology in our hospital were selected.According to the order number of outpatient visits,they were divided into experimental group and control group by random number table method,including 30 cases in experimental group and 30 cases in control group.Both groups of patients received oral methotrexate tablets as basic treatment.The experimental group was treated with Fumin Qingbi Granules on the basis of basic treatment,and the control group was treated with Shiduqing Tablets on the basis of basic treatment.The treatment period was 8 weeks.The VAS score of joint pain,TCM syndrome score,PSAI score,ESR,CRP,blood routine,urine routine,liver function,renal function and other important indicators were recorded and observed before and after a treatment cycle.After the treatment,statistics and data collation were carried out,and the results were obtained by statistical analysis.Finally,the results were evaluated according to the results.Results:1.There was no significant difference in gender,age,joint pain VAS score,TCM syndrome score,PSAI score,ESR and CRP between the two groups before treatment(P > 0.05).2.Comparison within the group,the VAS score of joint pain,TCM syndrome score,PSAI score,ESR and CRP of the two groups after treatment were significantly lower than those before treatment,and the difference was extremely significant(P < 0.01).3.Comparison between groups,compared with the control group,the VAS score of joint pain,TCM syndrome score,PSAI score,ESR and CRP improved more significantly in the experimental group after treatment,and the difference was statistically significant(P < 0.05).4.Comparison between groups,the clinical efficacy of TCM after treatment in the experimental group and the control group,the total effective rate of the experimental group was 83.33 %,compared with the total effective rate of the control group 76.67 %,the difference was statistically significant(P < 0.05).5.During the treatment of the two groups of patients,there were no abnormalities in blood routine,liver function,renal function,and urine routine examination.Conclusion:Compared with the control group,the TCM syndrome score,PSAI score,joint pain VAS score,CRP and ESR of the patients in the experimental group were better than those in the control group,and the clinical efficacy of the experimental group was more obvious,indicating that the overall efficacy of the Fumin Qingbi Decoction granule treatment group was better than that of the methotrexate tablet plus Shiduqing tablet treatment group,and no adverse events occurred during the treatment.It shows that the clinical efficacy and safety of Fumin Qingbi Decoction Granules are high,which can be used as a new choice for clinical treatment of this disease. |
