Clinical Study On The Combined Treatment Of Chinese And Western Medicine For Early Threatened Abortion With Kidney-Yin Deficiency

Objective: By observing the improvement of clinical symptoms and the effects of serum β-HCG,P,E₂ and B-ultrasound on patients with Kidney-Yin Deficiency type of early threatened abortion,we objectively analyzed and evaluated the therapeutic effects of combining Gushen Antai pill and dydrogesterone tablets,and conducted a preliminary discussion on its mechanism,with a view to providing a safe and effective method for the diagnosis and treatment of patients with early threatened abortion.Methods: A total of 60 patients with Kidney-Yin Deficiency type of early threatened abortion at 6-8 weeks of gestation（including 6 and 8 weeks）from November 2021 to November 2022 in the outpatient clinic of the Department of Reproductive Gynecology of the First People’s Hospital of Yunnan Province were selected and randomly divided into 30 cases each in the trial group and control group.The control group was given oral dydrogesterone tablets,while the test group was given oral Gushen Antai pill and dydrogesterone tablets.The treatment regimens of the two groups were compared for significant differences in terms of improvement in TCM syndrome score,serum β-HCG,P,E₂,B-ultrasound and overall clinical efficacy.Results:（1）TCM syndrome scores: There was statistically significant difference in the TCM evidence score between the two groups after treatment（P < 0.05）,suggesting that the test group could better reduce the TCM syndrome scores compared to the control group.（2）Serum β-HCG,P,E₂: Serum P and E₂ on day 7 of treatment and serum β-HCG levels on day 14 of treatment were higher in the test group than in the control group and there was a statistically significant difference.Difference in serum β-HCG levels on day 7 of treatment between the two groups was not statistically significant,but the test group was higher than the control group and was still considered clinically significant.Overall,as for serum pregnancy hormone levels’ raising,the test group has better Effects.（3）Ultrasound efficacy: For the test group,the total effective rate was 96.67%,and the control group was 90%.There was statistically significant difference,suggesting that the test group has better ultrasound efficacy.（4）Comprehensive Clinical Effectiveness: The recovery rate of the test group was 53.33%,the apparent efficiency was 30.33%,the effective rate was 10.00%,and the total effective rate was 96.67%,while the recovery rate of the control group was 23.33%,the apparent efficiency was 43.33%,the effective rate was 23.33%,and the total effective rate was 90.00%.Difference between the two groups was statistically significant,indicating that the test group has better combined clinical efficacy.（5）Follow : A total of 28 and 27 cases were followed up in the trial and control groups.1 pregnancy failed in the trial group and 27 continued,with a continuation rate of 96.43%,while 4 pregnancies failed in the control group and 23 continued,with a continuation rate of 85.19%.There was no statistically significant difference between the two groups,but the continuation rate was higher in the trial group than in the control group and was still considered clinically significant.Conclusion: The combination of Gushen Antai pill and dydrogesterone tablets in the treatment of Kidney-Yin deficiency type of early threatened abortion can significantly alleviate the clinical symptoms of patients,and has greater advantages in the improvement of pregnancy hormone levels and the reduction of the TCM evidence score than the application of dydrogesterone tablets alone,and has no significant toxic side effects,with positive and reliable results.