| Objective:To study the comparison of cure rate and recurrence rate of CA patients treated with conventional treatment and combined treatment with modified Sini Powder,as well as the comparison of homocysteine and cystatin C before and after treatment,and statistical analysis of anxiety and depression rating scale and quality of life questionnaire,so as to provide theoretical basis for exploring the treatment of CA patients with anxiety and depression with modified Sini Powder.Method: This study found that 4 cases fell out and 70 individuals who met the criteria were enrolled.Ultimately,66 patients from the Dermatology Department of the Second Hospital of Yunnan Province and the Yunnan Hospital of Traditional Chinese Medicine were stochastically assigned to two groups,33 patients in one group and 33 patients in the other group。All 66 patients had interferon intramuscular injection and wart excision using a microwave.Sini powder was given orally to the observation group.The therapy plan lasted for two months.The two patient groups’ quality of life scores,recurrence rates,anxiety and depressive symptom scores before and after treatment,and serum homocysteine and cystatin C levels were tracked and compared to assess the therapeutic significance.Result:(1)Overall effective rates:In the observation group,29 cases were cured(87.9%)and 4cases relapsed(12.1%).In the standard treatment group,20 cases were cured(60.6%),while13 cases relapsed(29.4%).Both groups’ recovery and recurrence rates were statistically significant(P<0.05).(2)Hcy Expression: After treatment,the treatment group’s expression of Hcy was downregulated,and there were marked differences between the two groups(P<0.05).Compared with the control group,there was a marked difference in the expression of Hcy protein between the two groups(P>0.05).After treatment,there was no discernible difference between the two groups in the expression of Hcy(P>0.05).These findings suggested that the treatment group did not clearly have a benefit in controlling Hcy expression.(3)Cys C expression: Cys C reduced in both groups following treatment,and There was no significant difference between the two groups(P>0.05).The difference between the two groups was not statistically significant(P>0.05).There was no significant difference in the regulation of Cys C between the two groups.(4)SAS and SDS expression: Following therapy,compared with the control group,the SAS and SDS in the treatment group were significantly reduced(P<0.05),and there was a statistically striking variance between the two groups.(P<0.05).Significant difference between the two groups(P <0.05).(5)CECA10 expression: After treatment,CECA10 in both groups increased significantly(P<0.05).There was significant difference between the two groups(p<0.05).Conclusion:(1)Modified Sini Powder combined with conventional therapy can effectively treat CA patients with anxiety and depression,with a significantly higher cure and recurrence rate than conventional therapy alone.(2)Both the observation group and the basic treatment group reduced Hcy,but the TCM observation group had no discernible advantage.Both groups had no significant effect on Cys C value improvement.(3)Both the observation group and the basic treatment group could reduce the SAS and SDS scores of patients and effectively improve the quality of life of patients,but the addition of Chinese medicine was significantly better than conventional treatment. |
