Observation Of The Efficacy Of Xingnaojing Injection In The Treatment Of Acute Ischemic Stroke And Its Effect On Serum IL-6 And TNF-α Levels

Objective:To evaluate the efficacy,safety and possible mechanism of Xingnaojing injection in the treatment of acute ischemic stroke(phlegm-heat fu-solid type)Methods:90 patients with acute ischemic stroke(phlegm-heat fu-solid type)meeting the inclusion criteria were randomly divided into treatment group and control group,with 45 cases in each group.The former shall be treated with conventional Western medicine combined with Xingnaojing injection,while the latter shall be treated with conventional Western medicine for a course of 10 days.At the end of the session,NIHSS Scale,Steoke-PRO Scale,ADLScale,mRS Scale,laboratory indexes IL-6 and TNF-αwere observed before and after treatment in two groups.To evaluate the clinical safety of Xingnaojing injection.Results:(1)There was no significant difference in IL-6 and TNF-α inflammatory factors between the two groups before treatment(P>0.05).On the 10th day of treatment,both IL-6 and TNF-α were decreased compared with that before treatment(P<0.01).Compared with each other,the decrease degree of treatment group was more obvious(P<0.01).On the 10th day of treatment,PRO scores in psychological field,social field,therapeutic field and total score of the two groups had no statistical significance(P>0.05).There were significant differences in physiological scores(P<0.05).(2)There was no significant difference in NIHSS score between the two groups before treatment(P>0.05).On day 7 of treatment,NIHSS score was decreased in both groups(P<0.05),but there was no significant difference between groups(P>0.05).On day 10 of treatment,there was statistically significant difference between groups(P<0.05),and the decrease was more obvious in the treatment group.(3)At 30 days after treatment,BI index and mRS Scores were significantly different between the two groups(P<0.05).At 90 days after treatment,BI index and mRS Score in the treatment group were significantly higher than those in the control group(P<0.01).(4)The proportion of relative independents in the treatment group(83.7%)was significantly lower than that in the control group(62.8%)at 90 days after treatment(P<0.05).(5)During treatment,adverse reactions occurred in both groups,but there was no statistical significance(P>0.05).Conclusions:(1)Early use of Xingnaojing injection in the treatment of AIS has positive significance in terms of symptoms and self-care ability of patients,and has high safety.(2)Xingnaojing injection may play a therapeutic role by reducing the levels of IL-6 and TNF-α in patients with AIS.