| Objective: To investigate the epidemiological characteristics of infant colic(IC)in Jinjiang area,and explore its potential related factors.Methods: From October 2017 to October 2020,All infants aged 1-3 months who taken health checkup and received follow-up,selected from Department of children healthcare in Jinjiang Maternal and Child Health Hospital,Jinjiang municipal hospital,Meiling aera of Jinjiang municipal hospital.The infant’s parents(caregivers)were assigned to conduct on-site questionnaires,medical history inquiry,physical examination and related necessary auxiliary examinations.The history inquiry and physical examination were performed again at the age of 3,6,9,and 12 months.The diagnosis of infant colic and other infant functional gastrointestinal disorders according to "Children’s Functional Gastrointestinal Disorders-Rome Ⅳ Standards".SPSS25.0 software was used for data processing and analysis.Results:(1)80(3.3%)infants met the Rome Ⅳ Standards for IC among 2397 infants which were selected,Including 56(70%)male infants and 24(30%)female infants,the rate of male to female is 2.3:1.In these colic infants,53 cases(66.25%)cominded with infant regurgitation,9 cases(11.25%)cominded with dyschezia,3 cases(3.75%)cominded with functional constipation,4 cases(5.0%)cominded with functional diarrhea.Among 2317 infants who were not diagnosed with IC,1027(44.3%)had infant regurgitation,333(14.4%)had dyschezia,87(3.8%)had functional constipation,88(3.8%)had functional diarrhea.For it,the crying time was 4.0±1.4hours per day,the first onset age of colic was 27.4±19.5 days,the frequency of crying was 4.2±2.3 per day,the course of colic was 59.6±25.9 days,53 cases(66.3%)occurred at night,10 cases(12.5%)occurred during the day,and 17 cases(21.2%)occurred at night and day.Divide the 80 cases of IC into a isolated IC group(group A,n=20)and combined with other FGIDs group(group B,n=60).Used the rank sum test,and the result showed there was no significant difference in crying time,the first onset age of colic,the frequency of crying and the course of colic of the two groups(P>0.05).(2)Taken healthy infants without FGIDs as the control group and infants with IC as the case group,the univariate χ2 test was performed.The results showed that gender,parity,abortion or not,father’s past diseases,and mother factors such as partial eclipse during pregnancy,pregnancy dietary taboos,eating fast food frequently during pregnancy,the time to add Vit D3 of the infant,probiotics supplementation after birth,the history of the mother’s FGIDs,and the history of the father’s FGIDs are associated with the occurrence of IC(P < 0.05).Taken the above-screened factors associated with IC as the independent variables,and taken the occurrence of IC as the dependent variables,the unconditional logistic binary regression analysis with stepwise forward method was performed.The results showed that gender was male(regression coefficient B=0.752,P=0.004),abortion(regression coefficient B=0.595,P=0.028),history of mather’s FGIDs(regression coefficient B=1.033,P=0.000),mother partial eclipse during pregnancy(regression coefficient B=0.655,P=0.039)and probiotics supplementation after birth(regression coefficient B=0.775,P=0.001)were risk factors for IC.Second or more birth(regression coefficient B=-0.506,P=0.039)was a protective factor to avoid IC.(3)The Well-being Index Scale(WBIS)and questionnaire survey were used to evaluate the impact of IC on family life.Taken 56 infants with IC who had complete family life assessment as the case group,and 587 healthy infants without IC and other FGIDs who had complete family life assessment as the control group.The χ2 test analysis was used to evaluate the family life between the control group and the case group.The results showed that compared with the group without IC,the happiness of family life with IC was worse(χ2=14.526,P=0.000),and the mother-infant interaction(χ2=9.413,P=0.000),and father-infant interaction(χ2=7.129,P=0.001)were poor too,and there was a statistical difference between the two groups(P < 0.05).However there was no statistical difference in mother-father interaction(χ2=1.607,P=0.205)and adverse family life events(χ2=0.675,P=1.000)between the two groups.Conclusion: The prevalence of IC in Jinjiang area was 3.3%.IC was often associated with infant regurgitation,and more occurred at night.Male infant,abortion,history of the mother’s FGIDs,partial eclipse during pregnancy,and probiotics supplementation after birth were risk factors for IC.Second or more birth was protective factor to avoid IC.IC may affected the happiness of family life,mother-infant and father-infant interaction. |
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