| Objective:To observe the clinical efficacy and safety of Anti-thirst Acupuncture combined with Xiaoke Antang Formula in treating diabetic peripheral neuropathy with Qi and Yin deficiency and stasis.Methods:Ninety patients with DPN who had Qi and Yin deficiency and stasis were randomly divided into three groups,with 30 patients in each.The Western medicine group received treatment with methylcobalamin tablets and lipoic acid injection;the Chinese medicine group additionally received treatment with the Anti-thirst Acupuncture combined with Xiaoke Antang Formula;and the needle medicine group received Anti-thirst Acupuncture infusions.Before and after the intervention,the patients in the three groups were assessed for changes in the TCM evidence score,Toronto clinical score(TCSS),fasting blood glucose(FPG),2 hours postprandial glucose(GSP),SF-36 quality of life score,safety indices(blood routine,liver and kidney function,electrocardiogram,acupuncture accidents,adverse reactions),and the SF-36 quality of life score.To unbiasedly assess the therapeutic efficacy and safety,the obtained data were statistically evaluated with SPSS26.0.Results:1.Before and after the intervention,the patients in the three groups were assessed for changes in the TCM evidence score,Toronto clinical score(TCSS),fasting blood glucose(FPG),2 hours postprandial glucose(GSP),SF-36 quality of life score,safety indices(blood routine,liver and kidney function,electrocardiogram,acupuncture accidents,adverse reactions),and the SF-36 quality of life score.To unbiasedly assess the therapeutic efficacy and safety,the obtained data were statistically evaluated with SPSS26.0.2.Clinical effectiveness: Following treatment,the clinical effectiveness of the three patient groups was compared.the effectiveness of the needle group was90%,the effectiveness of the Chinese medicine group was 66.66%,and the effectiveness of the western medicine group was 43.33%.The differences between the groups all showed significant significance(P<0.05),indicating that the needle group’s clinical efficacy was significantly higher than that of the Chinese medicine group and the western medicine group.The Western medicine group’s clinical effectiveness was much lower than that of the acupuncture group.3.After receiving treatment,patients’ TCM syndrome scores decreased to varying degrees in all three groups,with the differences demonstrating significant significance(P<0.05).The acupuncture group’s decrease in TCM syndrome scores was significantly better than that of the Western medicine group(P < 0.01)and the Chinese medicine group(P < 0.01).The TCM syndrome points fell significantly after treatment,and the differences demonstrated considerable significance(all P < 0.05),with the Chinese medicine group experiencing a significantly better decline in the TCM syndrome points than the Western medicine group(P<0.01).4.In terms of clinical scores in Toronto: the differences in TCSS before treatment were not significant(P > 0.05)and were comparable;after treatment,the TCSS of patients in all three groups decreased to different degrees than before,and the differences showed significant significance(P<0.05);by intergroup comparison,the decrease in TCSS in the needle medicine group was significantly better than that in the western medicine group(P<0.01)and the traditional Chinese medicine group(P<0.01);by intra-group comparison,the decrease in TCSS in the traditional Chinese medicine group was significantly better than that in the western medicine group(P<0.01).(P< 0.01),and the decrease in TCSS in the Chinese medicine group was significantly better than that in the western medicine group(P < 0.01);by intra-group comparison,the TCSS decreased significantly after treatment,and the differences showed significant significance(all P<0.05).5.In terms of glucose metabolism: the differences in FPG,2h PG,and GSP were not significant(P>0.05)before treatment in the three groups of patients,and were comparable;after treatment,the differences in FPG,2h PG,and GSP were not significant(P>0.05)in the three groups of patients,indicating that the differences in FPG,2h PG,and GSP decreased between the three groups after treatment were not significant.After intra-group comparison,compared with before receiving treatment,FPG and 2h PG of the three groups of patients,all P > 0.05,the difference was not significant;while P<0.05 of GSP of the three groups of patients,the difference showed significant significance,indicating that the GSP decreased significantly after treatment compared with before.6.Quality of life: The differences in the physical health dimension score(PF),physical role function dimension score(RP)and social function dimension score(SF)of the SF-36 quality of life scores of the three groups of patients before treatment were not significant(P>0.05)and were comparable;after treatment,the differences in RP were not significant(P>0.05),and PF and SF were significantly higher than before.After treatment,there was no significant difference between the three groups in terms of RP(P>0.05),but PF and SF improved to different degrees,and the differences were all significant(P<0.05);by comparison between groups,the PF and SF in the needle group improved significantly better than those in the Western medicine group(P<0.01 or P<0.1)and the Chinese medicine group(both P<0.1),and the PF and SF in the Western medicine and Chinese medicine groups improved basically similarly(P>0.05);by comparison within groups,PF and SF improved significantly after treatment compared with those before,and the differences were all significant.The differences were significant(P<0.05).7.The patients in the three groups had stable vital signs during the treatment,no abnormalities in blood routine,liver and kidney function,and electrocardiogram,and no acupuncture accidents or adverse drug reactions occurred,indicating that the safety of the three treatment methods was good.Conclusion(s):The combination of wrist and ankle acupuncture and thirst-quenching sugar formula for the treatment of diabetic peripheral neuropathy with Qi and Yin deficiency and stasis can improve the clinical symptoms,signs and quality of life to a certain extent,and the clinical efficacy has improved,safe and reliable. |
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