Study On Standardization Of Combined Treatment Technique Of Mongolian And Western Medicine In Convalescent Stage Of Shuisha Disease

Objective: To evaluate the efficacy and safety by observing the clinical efficacy of combining Mongolian and Western medicine in the treatment of Shuisha disease in the convalescent stage,and to develop the technical optimization plan of combining Mongolian and Western medicine in the convalescent stage,so as to provide clinical basis for the "Guidelines for Combining Mongolian and Western Medicine in the convalescent Stage".Methods: Among the inpatients admitted to the second Department of Encephalopathy and the Department of Neurological Rehabilitation of the Affiliated Hospital of Inner Mongolia Minzu University during2021-12-01 to 2022-12-31,180 patients in the convalescence stage of Shuisha disease were numbered according to the inclusion and exclusion criteria,and randomly divided into 3 groups with 60 cases each by means of random number table.All the 3 groups were given basic Western medicine treatment.Control group: aspirin 100 mg once a day orally,Atorvastatin calcium tablets20 mg once a day orally + Mongolian medicine Shusa disease nursing.Experimental Group A: Aspirin 100 mg daily,Atorvastatin calcium tablets20 mg daily.Shengyang 11 Wei Pills 3g warm water after breakfast,Eridun Ujile 3g warm water after lunch,Garidi 13 Wei pills 1.5g warm water before going to bed + Mongolian medicine Shusa disease nursing.Experimental Group B: Aspirin 100 mg orally,Atorvastatin calcium tablets 20 mg orally once a day.Shengyang 11 Wei Wan 3g warm water after breakfast,Eridun Wujile 3g warm water after lunch,Gaadi 13 Wei Wan 1.5g warm water before going to bed,Mongolian acupuncture therapy(0.5-0.8 inch flat acupuncture is used at Dinghui point,Meizhan point,neck concave point and ear back point according to the condition.Direct acupuncture at shoulder point,deltoid point,elbow point,wrist cross back point,thumb finger joint point,hip point,thigh point,shin point,toe point,foot ten toe point and other acupoints 1.0-1.5inches,and leave the needle for 20 minutes each time for acupuncture therapy.5 times a week),Mongolian moxibustion therapy(according to the condition of the selection of Heyi point,Badagan point,Dinghui point,Huoshuai point,black and white point and other traceless moxibustion method of ginger moxibustion 5-20 minutes according to the patient’s tolerance adjustment,once a week)+ Mongolian medicine water sa disease care,the total course of treatment is 1 month.Observation and record before treatment,after treatment,1 month follow-up,2 months follow-up,the score of each scale at each time point;The physical and chemical indexes were examined before and after treatment to evaluate its clinical efficacy and safety.Finally,the data were statistically processed by SPSS 26.0.Results:1.Efficacy observation indicators: analysis of correlation scale score:analysis of NIHSS scale: Scores of the three groups were decreased in each treatment segment,and there were significant statistical differences before and after treatment P < 0.01.These results indicated that the three groups were effective in the recovery of neurological defects.The comparison among the three groups showed that the score of experimental group A was lower than that of control group at all stages,with statistical difference P < 0.05;The score of experimental group B was lower than that of experimental group A at all stages,with statistical difference P < 0.05.Mongolian medicine symptom scale score analysis: there were statistical differences before and after treatment.These results showed that the three groups were effective in improving the clinical symptoms of Shusa disease.The comparison among the three groups showed that the score of experimental group A was lower than that of control group at all stages,with statistical difference P < 0.05;The score of experimental group B was lower than that of experimental group A at all stages,with statistical difference P < 0.05.BI index analysis: BI index mainly evaluates patients’ ability of daily living.The scores of the three groups were improved in each treatment stage,and there were statistical differences before and after treatment P < 0.01.These results indicate that the three groups have curative effect in improving the quality of life.Compared among the three groups at the same time,the score of experimental group A was higher than that of control group at all stages,with statistical difference P< 0.05;The score of experimental group B was higher than that of experimental group A in each stage,with statistical difference P < 0.05.Score analysis of modified Rankin Scale: The scores of the three groups were decreased at each stage of treatment,and there were statistical differences before and after treatment,P < 0.01,indicating that the three groups were effective in the recovery of neurological impairment.The comparison among the three groups showed that the score of experimental group A was lower than that of control group at all stages,with statistical difference P < 0.05;The score of experimental group B was lower than that of experimental group A at all stages,with statistical difference P < 0.05.Analysis of safety indicators: TG and LDL-C were decreased in the three groups before and after treatment,with statistical significance P < 0.01,which may be related to oral atorvastatin.The other physical and chemical indexes and electrocardiogram of the three groups were compared before and after treatment(P > 0.05),without statistical significance.2.Clinical effective rate: NIHSS score showed that the total effective rate was89.0% in experimental group B,84.0% in experimental group A,80.0% in control group,and Chi-square test analysis showed statistically significant differences(P < 0.05).The total effective rate was 88.0% in experimental group B,84.0% in experimental group A and 68.0% in control group,and there were statistical differences among the Chi-square test analysis(P <0.05).3.Safety indicators: The physicochemical indicators and electrocardiogram of patients in both groups were within the normal range before and after treatment,with no significant changes.Conclusion:1.The combination of Mongolian and Western medicine in the treatment of Shuisha disease in the convalescence stage has good therapeutic effect and no adverse reactions,which is safe.2.Compared with the simple application of western medicine,Mongolian and Western medicine combined with drug therapy has more advantages in the recovery of defective nerve function of patients in the convalescent stage of Shuisha disease.Compared with simple drug therapy,combined with external treatment of Mongolian medicine can further improve the quality of life of patients.