| Objective: This study aimed to explore the association between maternal age of menarche(MAM),Paternal and Maternal height,insulin-like growth factor-1 standard deviation scores(IGF-1 SDS),hemoglobin(Hb),the differences between the Bone age(BA)and age(CA)of children(△(BA-CA))and height standard deviation scores(Ht SDS)of children with short stature and the correlation between Maternal age of menarche(MAM)and metabolic indicators,to provide a clinical basis for the comprehensive assessment of the growth and development of children with short stature.Methods: A total of 529 children with short stature hospitalized in the Department of Endocrinology,Affiliated Hospital of Jining Medical University from March 2013 to February 2019 were included in this study.General information such as gender,age,growth history,height of parents,MAM,etc.,anthropometric indicators such as height,weight,blood pressure,etc.,were collected,and Body mass index(BMI)and Ht SDS were calculated,metabolic indicators such as TG,TC,HDL-c,LDL-c and FPG.Other laboratory indicators such as liver and kidney function,electrolytes,hemoglobin,thyroid function,Growth hormone peak(GH peak),Insulin-like growth factor-1(insulin-like growth factor-1),IGF-1)and the Insulin-like growth factor-1 standard deviation score(IGF-1 SDS)was calculated.The subjects were divided into two groups according to the Ht SDS level with-2.50 SD as the boundary point,and the differences between Ht SDS and MAM and other variables in the two groups were analyzed.According to MAM,subjects were divided into three groups: <13 years old,13～15 years old,and > 15 years old.The differences in various aspects of data among the three groups were compared,and finally the independent correlation between MAM and Ht SDS and metabolic indicators was analyzed.Results:1.The mean levels of Ht SDS and MAM were-2.63±0.59 and14.8±1.7 years,respectively.Compared with the-2.00 to-2.50 SD group,the △(BA-CA)(P<0.001),Paternal and Maternal Height(P<0.05),IGF-1SDS(P=0.011),MAM and HDL-c levels(P<0.05)were lower in the <-2.50 SD group,and the differences were statistically significant.There were no significant differences in CA,SBP,DBP,TG,TC,LDL-C,FPG,ALT and Cr between the two groups(P>0.05).Among different groups of MAM,there were statistically significant differences in the △(BA-CA),Ht SDS,TC,the ratio of male to female and the ratio of adolescent state(P<0.05).There were no significant differences in BMI,SBP,DBP,TG,LDL-C,FPG,ALT and Cr,etc.among the three groups(P>0.05).2.Univariate correlation analysis showed that Ht SDS was negatively correlated with MAM(β=-0.128,P=0.003)and was positively correlated with Paternal Height(β=0.092,P=0.035),Maternal Height(β= 0.112,P=0.010),IGF-1 SDS(β=0.201,P<0.001),△(BA-CA)(β=0.228,P<0.001)and Hb(β=0.104,P=0.018).3.After adjusting for other confounding factors,multiple linear regression showed an independent negative correlation between Ht SDS and MAM(β=-0.115,P=0.007).and independent negative correlation with Paternal Height(β=0.10,P=0.021)、Maternal Height(β=0.118,P=0.007),IGF-1 SDS(β=0.182,P<0.001),△(BA-CA)(β=0.171,P<0.001),and no correlation with Hb(β=-0.011,P=0.862).4.Univariate correlation analysis between MAM and metabolic indexes in patients with short stature showed that MAM was significantly negatively correlated with TC(P=0.048),but not with BMI,SBP,DBP,Hb,UA,TG,HDL-c,LDL-c,and FPG(all P>0.05).After adjusting for other confounding factors,multiple linear regression showed that there was no significant correlation between MAM and TC(P=0.235).Conclusion: MAM was negatively correlated with Ht SDS in children with short stature,and no correlation with metabolic indicators,suggesting that attention should be paid to the height assessment of children with late MAM and providing a clinical basis for the comprehensive assessment of the growth and development of children with short stature. |
