| Objective: To investigate the correlation between serum uric acid(UA)and metabolic indicators in patients with type 2 diabetes mellitus(T2DM).Methods: This cross-sectional study included a total of 1538 patients aged ≥18 years and diagnosed with T2DM who were hospitalized at the Department of Endocrinology,Affiliated Hospital of Jining Medical College between 07/2017 and 10/2021.Relevant clinical characteristics,including anthropometric measurements(height,weight,waist circumference,blood pressure,etc.),biochemical parameters(liver function,kidney function,lipids,blood glucose,etc.),were measured in all participants.The correlation of multiple clinical indicators with each metabolic indicator in T2DM patients was observed using the univariate analysis module.Then,after adjusting for potential confounders,the relationships between UA and waist circumference,systolic blood pressure,triglycerides,and alanine aminotransferase were explored by smoothing curve fitting,respectively.Finally,multiple linear regression analysis was executed to further assess the independent correlations between UA and metabolic indices such as waist circumference,systolic blood pressure,triglycerides,and alanine aminotransferase.Results:1.Univariate analysis showed a positive correlation between UA and waist circumference(P<0.001).After adjusting for potential confounders,smoothed curve fitting observed a linear positive correlation between UA and waist circumference,and multiple linear regression analysis showed an increase in waist circumference of 1.27 cm for every 1 mg/dL increase in UA(β=1.27,95% CI=0.92,1.62;P<0.001).2.Univariate analysis showed a positive correlation between UA and systolic blood pressure(P=0.043),and after adjusting for potential confounders,a smoothed curve fit observed a linear positive correlation between UA and systolic blood pressure,and multiple linear regression analysis showed an increase in systolic blood pressure of 0.91 mmHg for every 1 mg/dL increase in UA(β=0.91,95% CI=0.18,1.63;P=0.014).3.Univariate analysis showed a positive correlation between UA and triglycerides(P<0.001),and after adjusting for potential confounders,smoothed curve fitting observed a linear positive correlation between UA and triglycerides,and multiple linear regression analysis showed an increase in triglycerides of 0.15 mmol/L for every 1 mg/dL increase in UA(β=0.15,95% CI=0.10,0.19;P< 0.001).4.Univariate analysis showed a positive correlation between UA and alanine aminotransferase(P<0.001),and after adjusting for potential confounders,smoothed curve fitting observed a linear positive correlation between UA and alanine aminotransferase,and multiple linear regression analysis showed an increase in alanine aminotransferase of 1.16 U/L for every 1 mg/dL increase in UA(β=1.16,95% CI=0.52,1.81;P<0.001).Conclusion: In patients with T2DM,UA is significantly correlated with waist circumference,systolic blood pressure,triglycerides,alanine aminotransferase and other metabolic indexes.UA levels may have a moderating effect on obesity,hypertension,hyperlipidemia and liver function abnormalities in T2DM patients,and changes in serum UA levels in T2DM patients should be closely monitored in clinical work. |
