Relationship Between Serum Uric Acid Level And The Metabolic Syndrome In Type 2 Diabetes

Objective: To study patients with type 2 diabetes serum uric acid concentration and metabolic syndrome and its components Waist, FPG, TG, HDL-C, SBP, DBP relationship, for the prevention, treatment of type 2 diabetes hyperuricemia, and interfere with large vascular disease and nephropathy provide the basis for the development.Target: test group from January 2007 to December 2008 in our hospital hospitalization metabolism Diabetes Center, according to WHO (1999 years) diagnostic criteria for the diagnosis of diabetes mellitus patients with type 2 diabetes 772 cases, 454 cases of male, female 318 cases, of which history records of 257 cases who had post-menopausal, age 23 to 87 years old, average 55.89±14.2 years; rule out kidney disease with diabetes mellitus, primary kidney disease, blood disease and recent use of antihypertensive drugs, medicines and other drugs which affect serum uric acid. The control group for a medical examination in our hospital 106 cases of healthy, male 40 cases, 66 cases of women, including those who have been 35 cases of post-menopausal, age 25 to 78-year-old, with an average age of 54.71±12.37. Methods:⑴collect general information on all objects such as age, medical history (including the history of menopause), waist circumference (Waist), systolic blood pressure (SBP), diastolic blood pressure (DBP), and biochemical indicators such as fasting plasma glucose (FPG), high density lipoprotein cholesterol (HDL-C), triglycerides (TG), creatinine (Cr), serum uric acid (UA), and 24-hour urinary albumin excretion rate;⑵by gender due to the concentration of UA, as well as the impact of estrogen levels, gender, post-menopausal women based on whether or not the object of the selected group, the experimental group is divided into male group, post-menopausal women and postmenopausal women are not unit based on IDF on the metabolic syndrome (MS) diagnostic criteria and divided into sub-group of MS and non-MS subgroup, the corresponding control group also divided into groups of men, postmenopausal women and postmenopausal women not groups;⑶respectively, for men, premenopausal women and postmenopausal women's group did not test group and the corresponding control group of UA concentration, the experimental group sub-group within the MS and non-MS subgroup compared the concentration of UA;, respectively, for men, premenopausal women and postmenopausal women not Group UA concentration and MS analysis for each component;, respectively, for men, premenopausal women and postmenopausal women did not group to UA as a result of multi-variable regression analysis;⑷using SPSS13.0 Statistical Package for statistical data processing, measurement data to mean±standard deviation ( x±s) described inter-group comparison analysis of variance, correlation analysis, using a simple correlation analysis and partial correlation analysis, regression analysis using stepwise regression analysis.Results:(1) male, postmenopausal women and postmenopausal women n ot UA concentrations are higher than those of the experimental group (P <0.05); prompt patients with type 2 diabetes increased serum uric acid levels.(2) pilot sub-group within the MS group was significantly higher than the concentration of UA non-MS subgroup (P <0.01), tips of the UA and MS.(3) UA and Waist, FPG, TG, HDL-C, SBP and DBP of the correlation analysis. Simple correlation analysis showed that serum uric acid was positively correlated with age (men, postmenopausal women and postmenopausal women in three groups of non-correlation coefficient of 0.175,0.127 and 0.152, respectively), adjusted for age of the partial correlation analysis showed that serum uric acid and Waist, TG, SBP and DBP was positively correlated with FPG, HDL-C was a negative correlation.(4) serum uric acid as the dependent variable to Waist, FPG, TG, SBP and DBP from the variables for the multiple stepwise regression analysis, Waist male patients with type 2 diabetes related factors independent of serum uric acid (R2 is 0.207, P <0.01) , Waist and TG female patients with type 2 diabetes independent of serum uric acid-related factors (Group R2-menopausal women were 0.253,0.128, both P <0.01; group R2 is not post-menopausal women were 0.316,0.178, both P <0.01).Conclusion:⒈Patients with type 2 diabetes increased levels of serum uric acid.⒉In Patients with diabetes mellitus ,serum uric acid associated with the metabolic syndrome.⒊waist circumference and blood triglyceride is a risk factor for increasing serum uric acid.