| Objective:To investigate the effect of aspirin on preeclampsia-related pregnancy outcomes,and to analyze the dosage.Methods Articles published between January 1978 and August 2021 were searched,and Review Manager 5.3 was used to evaluate the quality of the included literature,and to calculate the risk ratio(RR)or weighted mean difference(WMD)and 95%confidence interval(95%CI).Results:Aspirin can reduce the incidence of PE,preterm birth,PND,FGR,low birth weight and increase the risk of PPH.The dose of 75mg is the best for the prevention of PE,preterm birth,and FGR,80mg/81mg can reduce the risk of PND,and 60mg can increase the incidence of PPH.There was no apparent effect on the incidence of low birth weight at the various doses currently in use.However,it has no effect on adverse pregnancy outcomes such as gestational hypertension,stillbirth,placental abruption,NICU,and NIVH,and does not affect the mode of delivery.Comparing severe and mild PE,as well as early-onset and late-onset PE,aspirin has a better effect in severe and early-onset PE,and aspirin is more effective for preterm birth at gestational age<34 weeks than 34 weeks≤gestational age<37 weeks better trend.Conclusion:Aspirin has a significant effect on reducing the risk of severe PE,early-onset PE,preterm birth at gestational age<34 weeks,PND,and FGR.The dose of 75mg is the best for the prevention of PE,preterm birth,and FGR.80mg/81mg can reduce the risk of PND,and 60mg can increase the incidence of PPH.However,due to the failure to limit the use of drugs to start and terminate gestational age,the dose may exist bias.In the future,more experiments that strictly limit the initiation and termination of gestational age of the drug are needed to discuss the dose usage. |
