Study On Clinical Effect Of Different Low-doses Aspirin In Preeclampsia

Objective:Preeclampsia is a pregnancy induced hypertension in a class,divided into mild preeclampsia and severe preeclampsia,mild preeclampsia mainly for pregnancy after 20 weeks the systolic pressure is greater than or equal to 140 mm Hg and/or diastolic blood pressure more than 90 mm Hg,proteinuria,more than 0.3g/24 h,or random urine protein(+);if the blood pressure and urine protein increased,occurrence of maternal organ dysfunction or fetal complications for severe preeclampsia.Pregnancy induced hypertension is still one of the main causes of the adverse outcomes of pregnant and parturient women and fetal babies,and is a health problem facing all human beings.The incidence rate in China is 9.4% to 10.4%,of which about 15%~25% HDP with the progression of pregnancy and development of preeclampsia,accounting for 10% of the pregnancy related mortality rate to 16%,is the main cause of maternal death;in addition,the WHO survey of 29 development China home pregnancy worldwide for 2004~2008 years in the incidence of hypertension related diseases,found that the incidence of PE from Vietnam 0.2% to Nicaragua 7.67%,the average incidence rate was 2.16%;preeclampsia as an intermediate link of hypertension development during pregnancy,most patients often appear serious complications,and even have serious maternal and fetal adverse conditions before treatment,greatly increased mother and infant mortality.Therefore,it is necessary to take effective measures to prevent pregnancy induced hypertension.Aspirin(aspirin,acetyl salicylic acid),also known as phthalide salicylic acid,is a long history of antipyretic analgesics.It is used to treat cold,fever,headache,toothache,joint pain and rheumatism,and also can inhibit the aggregation of platelets.Aspirin is the earliest antiplatelet drug used in clinical practice.Pregnancy induced hypertension is the main cause of maternal death,and low-dose aspirin is possible by vasoconstriction and inhibition of thromboxane mediated immune regulation to prevent preeclampsia,improve pregnancy outcomes,this study aimed to study the effects of low-dose aspirin on clinical effect and improve the high-risk pregnancy outcomes of pregnant women with preeclampsia.Methods:This study selected in First Affiliated Hospital of Hebei North University from October 2015-June 2017 production inspection and delivery of preeclampsia in high-risk pregnant women 150 cases,randomly divided into the observation group A50 cases,B50 cases of the observation group,50 cases in the control group,the observation group A in pregnancy in 11+0 to 13+6 weeks of aspirin 100 mg,1 times / Japan;the observation group B,in pregnancy 11+0 to 13 + 6 weeks to give aspirin 75 mg,1 times /day,two groups were in control group before treatment;for the control,non intervention,pregnancy outcome were compared between the three groups of mother and child(incidence of preeclampsia,preeclampsia<37 week incidence.The incidence of severe preeclampsia,intrauterine growth restriction incidence rate,premature delivery rate,average weight,novice children positive rate of microalbuminuria,the rate of postpartum hemorrhage),long-term complications(postpartum year incidence of hypertension,microalbuminuria,half of newborn).The annual survival rate was compared.Results:The incidence of preeclampsia and severe preeclampsia incidence,the incidence of preeclampsia is less than 37 and the rate of fetal growth restriction,experimental group A and B were lower than the control group(P<0.05);no significant difference between the three groups in the rate of neonatal weight and preterm birth;the incidence of hypertension and microalbuminuria half a year later,the experimental group A and B were lower than the control group(P< 0.05).The rate of A and B in the experimental group was higher than that of the control group(P<0.05)for half a year.Conclusions:Low-dose aspirin(75mg and 100mg)can effectively prevent pre-eclampsia,improve maternal and child pregnancy outcomes,and reduce the incidence of long-term hypertension and kidney injury in pregnant women.Two small doses of aspirin did not increase the weight of newborn babies and did not aggravate postpartum hemorrhage.Therefore,it is recommended to use small doses of aspirin 75mg/ day to prevent pre-eclampsia.