A Meta-analysis Of Low-dose Aspirin For Prevention Of Preeclampsia

Objective: To evaluate the effectiveness of low-dose aspirin (LDA) in the prevention ofpreeclampsia in low-risk and high-risk women. Methods: We searched Pubmed(1995toaugust2012), MEDLINE(OVID1995to August2012), EMBASE(1995to August2012),Calis medalink(1995to August2012), Chinese Journal Full-text Database(CJFD)(1995to August2012), CNKI(1995to August2012), Wanfang database (1995to August2012)added with handsearching And other retrievals, The Cochrance Collaboration’sRevman5.0.18was used for meta-analyses. Results: fifteen randomized controlled trialswere available and were included in the study. Meta-analyses showed that LDA has asmall effect in the prevention of preeclampsia in women considered to be at high risk forthe disease(OR=0.83，95%CI0.71－0.96，P=0.02). but it is not effective in reducing therisk of preterm deliver(OR=0.84,95%CI0.64－1.10, P=0.21). there was overall onlymarginal reduction in the risk of FGR(OR=0.70,95%CI0.50－0.99, P=0.04). However, itis not effective in reducing the risk in the low-risk group(OR=1.07,95%CI0.90－1.27,P=0.42).Moreover,LDA was no beneficial in reducing the risk of preterm deliver(OR=0.67,95%CI0.42－1.07, P=0.09), there was no effective in reducing the risk of FGR(OR=0.97,95%CI0.83－1.13, P=0.69). Conclusion: LDA has a small effect in the prevention ofpreeclampsia and FDR in women consider to be at high risk for the disease. However, it isnot effective in reducing the risk in the risk in the low-risk group．...