Correlation Between Cognitive Function,event-related Potential And Serum Inflammatory Factors In Patients With First-episode Depressive Disorder

Objective:To explore the relationship between cognitive function and event-related potential P300 and serum inflammatory factors in patients with first-episode depressive disorder,to provide an objective combination of evaluation parameters for the early identification and diagnosis of cognitive impairment in patients with first-episode depressive disorder,and to better understand the first-episode depression.Impairment of cognitive function can be assessed to help treat and improve patient outcomes.Methods:According to the inclusion and exclusion criteria of this study,a total of 50 patients with first-episode depressive disorder without any treatment and 30 healthy controls were included.General demographic data of all subjects were collected,the severity of depressive symptoms was assessed using the Hamilton Depression Scale17-item(HAMD-17),and cognitive function of all subjects was assessed using RBANS and event-related potentials.Blood samples from both groups were collected and enzyme-linked immunosorbent assay(ELISA)was used to detect the levels of inflammatory factors in serum.MATLAB software was used to integrate the latency and amplitude values of the components related to the event-related potential,and then SPSS22.0 software was used for statistical analysis of the data.Results:1.In terms of RBANS,the depression group had lower scores in immediate memory,delayed memory,verbal function,attention score and total scores in RBANS than the control group,with statistically significant differences(P < 0.05 or P < 0.01).In the event related potential test,the latency of N1,P3 a and P3 b in the depression group was longer than that in the control group,and the amplitude of P3 a and P3 b was lower than that in the control group,with statistical significance(P < 0.05 or P <0.01).Compared with the control group,the levels of TNF-ɑ,CRP and IL-6 were higher in the depression group,and the differences were statistically significant(P <0.05 or P < 0.01).2.In the correlation analysis between the total scores of RBANS and factor scores and ERP-P300,it was found that the incubation period of P3 a was negatively correlated with immediate memory,delayed memory scores and the total scores of RBANS(r=-0.318,-0.444,-0.423;P < 0.05 or P < 0.01),and the amplitude was positively correlated with the attention score(r=0.387,P < 0.01).P3 b latency was negatively correlated with verbal function,delayed memory score and total scores in RBANS(r=-0.340,-0.384,-0.420;P < 0.05 or P < 0.01),the amplitude was positively correlated with immediate memory,verbal function,attention,delayed memory scores and RBANS(r=0.626,0.359,0.332,0.346,0.535;P < 0.05 or P < 0.01).3.Correlation analysis between RBANS scores,factor scores and inflammatory factors in depression group showed that IL-6 was negatively correlated with immediate memory,visual span,delayed memory scores and RBANS scores(r=-0.303,-0.313,-0.403,-0.506;P < 0.05 or P < 0.01);TNF-α was negatively correlated with immediate memory,verbal function,attention,delayed memory scores,and RBANS(r=-0.510,-0.374,-0.524,-0.445,-0.548;P < 0.05 or P < 0.01);There was no correlation between CRP and RBANS scores or factor scores(P > 0.05).4.Correlation analysis of inflammatory factors and ERP related components in depression group showed that IL-6 was positively correlated with latency of P3 a and P3b(r=0.281,0.411;P < 0.05 or P < 0.01);TNF-ɑ was negatively correlated with P3 b amplitude(r=-0.497;P < 0.05).5.Multifactor linear regression analysis of the effects of ERP-P300,IL-6,AND TNF-ɑ on the total scores in RBANS showed that the incubation periods of IL-6,TNF-ɑ,P3 a,and P3 b had an effect on the total scores in RBANS and were negatively correlated.(β=-0.342、-0.617、-0.351、-0.209;P < 0.05 或 P < 0.01)Conclusion:1.Patients with first-episode depressive disorder have multi-dimensional cognitive impairment,mainly manifested in memory loss,inattention,poor language fluency,and delayed response.The amplitude of P3 b is reduced;the levels of inflammatory factors CRP,IL-6,and TNF-α are higher than those of normal people,indicating that patients with first-episode depressive disorder are accompanied by high levels of inflammatory factors and ERP latency and amplitude changes.2.There is a correlation between ERP-P300 and inflammatory factors IL-6,TNF-α and cognitive impairment in patients with first-episode depressive disorder.The combination of neurophysiological and biochemical indicators can be used for early identification of cognitive impairment in patients with first-episode depressive disorder.Diagnosis provides objective assessment indicators to aid in treatment and improve patient outcomes.