Octa-based Study On The Control Of Myopia With Low Concentration Atropine Eye Drops

Obejective:OCTA was used to study the effect of low-concentration atropine eye drops on the microvascular system and structure of macular retina in children and adolescents,so as to analyze the mechanism of low-concentration atropine controlling myopia.Methods:A prospective randomized controlled study was conducted to select 131 children and adolescents who were diagnosed as myopic by dilated optometry and treated with low concentration atropine eye drops from September 2020 to August 2021 in the ophthalmology Center of the Second Affiliated Hospital of Nanchang University.The patients were divided into the low-concentration atropine eye drop treatment group(70cases)and the control group(61 cases).All participants receive equivalent spherical mirrors at baseline(SE),axial length(AL)and intraocular pressure(IOP)and central corneal thickness(CCT),the diameter of the pupil,corneal curvature,central anterior chamber depth(ACD),adjusting the amplitude(AMP),macular center concave choroid thickness(SFCT),composite shallow vessels under(SVC),deep vein complex(DVC,BLOOD flow density of choroidal capillaries(CC)and retinal thickness(RT)were examined and followed up twice at 3 and 6 months.SPSS 25.0 was used for data analysis.Mean ± standard deviation was used to describe the measurement data.Oneway ANOVA was used if the data met normal distribution;T test was used if the data met normal distribution between the medication group and control group.Kruskalwallis test was used for analysis of non-normal distribution.Results:1.General information: There was no significant difference in central corneal thickness(CCT),intraocular pressure(IOP),central anterior chamber depth(ACD)and corneal curvature after 6 months of local use of low concentration atropine eye drops,and there was no significant difference in the above indexes in the observation group compared with baseline and control group(P > 0.05).The pupil diameter and choroid thickness under macular fovea(SFCT)in the observation group increased,and the differences were statistically significant compared with baseline and control group(P< 0.05).The mean value of diopter and ocular axis in the observation group was slightly increased compared with the baseline,but there was no statistical significance compared with the baseline(P > 0.05).The progress value of diopter and ocular axis in the observation group was smaller than that in the control group,and the difference was statistically significant(P < 0.05).2.Blood flow density of macular microvascular system: Low concentration group atropine eye drops to treat macular microvascular system including SVC,DVC and CC at baseline,there was no statistical difference compared with control group difference(P > 0.05),while in 3 months,6 months follow-up,the blood flow density are higher than the control group and the baseline(see figure 3-1)and the difference is statistically significant(P < 0.05),In the control group,the mean blood flow density at 3 and 6months was lower than that at baseline,and the difference was not statistically significant(P > 0.05).3.Retinal thickness(RT): Low concentration group atropine eye drops to treat different macular RT at baseline,there was no statistical difference compared with control group difference(P > 0.05),low concentration group atropine eye drops to treat macular inner ring nasal side,outer ring temporal side in 3 months,6 months followup,its high RT than the control group,the difference statistically significant(P <0.05),The RT of the nasal side of external macular ring and the upper side of external macular ring in the low-concentration atropine eye drop treatment group was higher than that in the control group at 6 months follow-up,with statistical significance(P <0.05).The mean RT of the low-concentration atropine eye drop treatment group was slightly thicker at 3 and 6 months of follow-up compared with baseline,but the difference was not statistically significant(P > 0.05).In the control group,the mean value of RT at March and June decreased slightly compared with the baseline,with no statistical significance(P > 0.05).Conclusions:1.Local use of 0.01% low-concentration atropine eye drops can delay the progression of myopia;2.Local use of 0.01% low concentration atropine eye drops can improve retinal choroidal microcirculation;3.Local use of 0.01% low concentration atropine eye drops resulted in obvious thickening of choroid and slight thickening of retina.