| Objective:By observing the improvement of clinical symptoms,dyspnea degree(m MRC),lung function,chest CT imaging score and other indicators in the treatment of bronchiectasis by Maimendong Decoction combined with Liquorice Dried Jiang Decoction in the stable period of bronchiectasis,the clinical advantages of traditional Chinese medicine in the treatment of bronchiectasis were explored.At the same time,it provides theoretical and clinical basis for the clinical application and further promotion of this prescription.Methods:Will come from Rui kang affiliated hospital of guangxi medical university respiratory medicine outpatient and the inpatient treatment included in the standard of stabilization in 70 patients with bronchiectasis,according to random number table method were randomly divided into control group and treatment group,35 cases.Control group to small ROM erythromycin dose of150 mg/d,oral;Treatment group on the basis of the control group in radix ophiopogonis decoction and licorice root dry ginger soup to add and subtract treatment,two groups of continuous treatment for 3 months.Evaluation of two groups of patients before and 3 months after treatment the clinical curative effect,compare the extent of TCM syndrome integral,difficulty breathing(m MRC),pulmonary function,chest CT imaging score changes of the indicators.Results:(1)Comparison of clinical efficacy between the two groups: the total effective rate of clinical efficacy in the treatment group(87.88%)was higher than that in the control group(71.88%),and there was a difference(P<0.05).(2)Comparison of TCM syndrome score between the two groups:(1)Single TCM symptom score: there was no significant difference before treatment(P>0.05).The control group could improve the symptoms of cough,expectoration,fatigue,shortness of breath,dry mouth and no desire to drink,constipation(all P<0.05),but there was no significant effect in improving the symptoms of spontaneous sweating,night sweating,hand-foot-heart fever(P>0.05).The clinical symptoms of patients in the treatment group were significantly improved,and the symptoms of cough,expectoration,fatigue,shortness of breath,dry mouth without desire to drink,spontaneous sweating,night sweating and constipation were better than the control group(P<0.05).(2)Total score of TCM syndromes: there was no significant difference before treatment(P>0.05).After treatment,the TCM syndrome score of the two groups was lower than that before treatment(P<0.05),and the improvement of TCM syndrome score in the treatment group was significantly better than that in the control group(P<0.05).(3)Comparison of the degree score of dyspnea(m MRC)between the two groups: after treatment,the m MRC score in both groups was improved compared with that before treatment(P<0.05),but the m MRC score in the treatment group was better than that in the control group(P<0.05).(4)Comparison of lung function(FEV1%,FVC%)scores between 2groups: there was no significant difference before treatment(P>0.05),and after treatment,FEV1% and FVC% were slightly higher than before treatment,but there was no statistical significance between groups and within groups(P>0.05).(5)Comparison of chest CT imaging scores between the two groups:(1)Single score of chest CT imaging was comparable before treatment(P>0.05).There was no significant difference between the two groups(P>0.05),indicating that the two groups had no significant improvement in the score of the diseased lung.The difference was statistically significant within the group and between groups after treatment(all P<0.05),indicating that both groups could improve the area score of dilated bronchus and surrounding lesions in the lung,but the treatment group was better than the control group.The score of dilated bronchial tube wall thickness was compared within the group and between groups after treatment(all P<0.05),indicating that the score of dilated bronchial tube wall thickness was improved in both groups,but the improvement in the treatment group was better than that in the control group.(2)the chest CT imaging total score: no significant difference(P>0.05)before treatment and after treatment in two groups of patients with chest CT imaging total score was to reduce the(P<0.05),but the treatment group after treatment chest CT imaging total score than the control group decreased significantly(P<0.05),the treatment group to improve the chest CT imaging total score is better than the control group.(6)Safety analysis: During the current project trial,no adverse drug reactions occurred in the two groups of patients,and no obvious abnormalities appeared in body temperature,breathing,pulse,blood pressure,three major routines,liver and kidney function,and electrocardiogram.Conclusion :(1)Maimendong Decoction combined with liquorice dried jiang Decoction combined with low-dose roxithromycin can effectively relieve the clinical symptoms of patients with phlegm and Yin deficiency in stable stage of bronchiectasis,especially in cough,expectoration,fatigue,shortness of breath,dry mouth without desire to drink,spontaneous sweating,night sweating,constipation and other symptoms;(2)Radix ophiopogonis decoction and licorice root dry ginger soup to add and subtract in combination with small dose of luo erythromycin treatment of bronchiectasis disease stabilization gas Yin deficiency of phlegm retention syndrome in clinical efficacy,TCM syndrome integral,improved dyspnea score(m MRC),chest computed tomography(CT)imaging score(accounted for in the lung lesions in the dilated bronchi and the surrounding area of a grade,the expansion of the bronchial wall thickness and the total score)And the degree of improvement was better than that of oral low dose roxithromycin.(3)There was no significant improvement in lung function(FEV1%,FVC%)of patients with stable bronchiectasis syndrome with deficiency of Qi and Yin combined with phlegm-drinking syndrome in Maimendong decoction and liquorice-dried jiang Decoction combined with low-dose roxithromycin and low-dose roxithromycin alone. |
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