| Objective: To observe the therapeu tic effect of Kangfuxin Liquid on different physiqu e thin endometriu m.Methods: 1.case sources: Fro m September 2018 to December 2019,th in endometrial patien ts were collected from th e tutor’s clinic of traditional Ch inese Medicine Affiliated Hospital of Ch engdu University of traditional Ch inese medicine.2.research method: 168 cases of thin endometrial p atien ts were collected by using outpatien t medical record and TCM body mass table;The physical transformation score and physical distribu tion of each patient were calcu lated to explore th e physical distribu tion char acteristics of thin endometrium;Three kinds of Constitu tion with the largest population d istribution were selected,each of which was a group,38 with Qi deficiency,33 with Yang deficiency and 32 with b lood stasis;Each gr oup was treated with Kangfux in Liquid orally,with differen t doses and frequencies,10 mltid for mild,20 mltid for moderate,30 mltid for serious.The treatment was s tarted on the second day after the menstruation was clean.The drug was stopped during menstruation.One menstrual cycle was reg arded as one course,and on e course was treated accord ing to th e incr ease o f endometr ium;The clinical observation indexes of Kangfuxin Liquid includ e body fraction,menstrual vo lume in tegral,endometrial thick ness in the middle of luteum,RI and PI of endometrial blood supply in the middle of luteum,FSH,LH and E2 in ovulation.The d ifferen ce b efore and af ter tr eatment was statistically significan t,which was eff ective.Spss25.0 was used for data statistics in th e three groups.Results: 1.According to the in clusion ex clusion cr iter ia,168 cases of thin endometriu m were collected.According to th e distribu tion of constitu tion tr ansformation,the thr ee cons titu tion with the larg est numb er of peop le ar e Qi d eficiency quality > Yang def iciency quality > blood s tasis quality;38 people are Qi deficiency qu ality,accounting for 22.6%;33 people are Yang def icien cy quality,accounting for 19.6%;32 people are blood stasis quality,accoun ting for 19.0%;2.The average age of the qi deficiency quality g roup was(31.79±3.54)years;The aver age age of the yang d eficiency quality was(33.18±4.13)years;Th e average ag e of the blood stasis group was(31.41±4.79)years;Ther e was no significan t diff erence in age among the thr ee groups(P>0.05);There was no significan t diff erence in compar ison of oper ation in uter ine cavity among of the thr ee groups(p>0.05);Ther e was no sign ificant differen ce in co mparison of course of disease compos ition ratio between groups.3.Before and after the treatmen t,the constitution fraction of th e qi def iciency quality group was [57.14(54.02~67.32)vs50(42.30~60.16)];Menstrual volume integral was [24(14 ~ 38)vs28(25 ~ 45)];Mid luteal endometrium thickness was [0.5(0.5~0.6)cmvs0.7(0.6~0.8)cm];RI of mid luteal endometrium was(0.61±0.08)vs(0.52±0.09);PI of mid luteal endometrium was 0.85±0.21vs0.69±0.21;Th ere was no significan t diff erence in co mparison ov ulation FSH,LH,E2 b etween before and af ter the treatmen t.4.Before and after the tr eatment,th e constitution fraction of the yang deficiency quality group was [65.63(62.5~68.75)vs62.5(53.35~71.88)];Menstrual volume integral was [22(17~33.5)vs30(29~49.25)];Mid luteal endometrium thickness was [0.6(0.5 ~ 0.7)cmvs0.9(0.65 ~ 0.9)cm];RI of mid luteal endometrium was(0.59±0.07)vs(0.52±0.10);PI of mid luteal endometrium was(0.86±0.15)vs(0.75±0.22);Ther e was no significant differ ence in compariso n ovulation FSH,LH,E2 between before and af ter the treatmen t.5.Before and after the tr eatment,th e constitution fraction of the blood-stasis quality group was [62.50(54.46~71.43)vs53.57(45.98~57.14)];Menstrual volume integral was [20(18~28.25)vs25(21.75~33)];Mid luteal endometrium thickness was [0.6(0.5~0.7)cmvs0.8(0.6~1.0)cm];RI of mid luteal endometrium was(0.59±0.09)vs(0.48±0.08);PI of mid luteal endometrium was(0.97±0.21)vs(0.59±0.19);Ther e was no significant diff erence in comp arison ovulation FSH,LH,E2 between before and af ter the treatmen t.6.Correlation indicators were comp ared between groups before and after treatment,the q i deficien cy quality gro up was compared with th e yang-asthenic-quality group,th e blo od-stasis group and th e yang-asthenic-quality group after treatment;Th ere was no statistical significan ce in the in tergroup compar ison of menstrual volume score,endometr ial thickn ess,RI in luteal metaphas e,FSH,LH and E2 in ovulation before and after treatment;After treatment,the comparison between th e groups showed that th e differ ence of PI betw een the qi-def iciency group and the blood-stasis group,the blood-stasis group and the yang-deficien cy group was statistically signif ican t diff erent(p<0.05),while the d ifferen ce b etween the qi-deficiency group and the yang-deficiency group was not statistically significan t(p>0.05).Conclusion: 1.The three constitution types with the larg est distribution of thin endo metr ium: qi-asthenia >yang-asth enia >b lood stasis;2.Kangfuxin solution can improve th e symptoms of the thin endometriu m with deficiency of qi,deficiency of Yang and blood stasis,and increase th e endometr ial thickn ess;3.Kangfuxin solution cou ld improv e subendometrial b lood supply in the middle luteal period of the qi-deficiency grou p,yang-deficiency group and blood-stasis group,and the improvemen t was most obvious in the blood-stasis group. |
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