| Research Background:Cancer related fatigue(CRF)is one of the most common and severe subjective accomPanying symPtoms of tumor Patients,with an incidence of 59%to 99%[1-2].About 65%-100%receiving chemotheraPy and 82%-96%of tumor Patients receiving radiotheraPy will exPerience varying degrees of CRF[3].CRF can run through the entire Process of tumor occurrence,develoPment,treatment and Prognosis[4],which seriously affects the treatment comPliance and quality of life of Patients.CRF not only It brings Physical and Psychological burdens to Patients,and also brings treatment Problems to clinicians.Studies have found that the degree of malnutrition is Positively correlated with the formation and develoPment of CRF[5-6].In order to imProve the symPtoms of CRF in Patients with malnutrition,it is necessary to exPlore new treatments for CRF.Skeletal muscle is the main comPonent of the body's lean tissue grouP.The loss of lean tissue grouP will directly affect the clinical outcome of Patients.Patients with dystroPhic tumors are mainly manifested by increased skeletal muscle consumPtion and metabolic abnormalities,including decreased muscle mass,quantity,strength,and oxidation caPacity,and thus fatigue.At the same time,the energy suPPly of cancer Patients is mainly Provided through glycolysis.The glycolysis Pathway can lead to excessive Production of lactic acid,insufficient ATP synthesis inmuscle tissue,decreased muscle contraction function,and fatigue.D-ribose is a kind of Monosaccharides can quickly rePlenish ATP for skeletal muscles by accelerating ATP's heavy and remedial synthesis Pathways to achieve anti-fatigue effects.Preclinical studies suggest that suPPlementing D-ribose can alleviate fatigue and enhance exercise endurance in mice[7-9].Objective:To exPlore the effect of D-ribose combined with nutritional suPPort on imProving the symPtoms of CRF in malnourished tumor Patients,and to Provide clinical evidence for D-ribose to imProve the symPtoms of CRF in tumor PatientsMethods:ProsPective,oPen,case-control method.The SimPle Fatigue Inventory(BFI)and the PiPer Fatigue Self-Rating Scale(PFS-R)are used as evaluation tools to assess the fatigue state of Patients,and the Self-Rating Anxiety Scale(SAS)and DePression Self-Rating Scale(SDS)are used to evaluate Patients To assess the nutritional status of cancer Patients,the subjective overall nutritional status rating scale(PG-SGA),Physical Performance score(ECOG),and BMI were used to assess the nutritional status of cancer Patients.The inclusion conditions were as follows:PG-SGA was grade B and/or C,and BFI table was used to evaluate? 4 tumor Patients.A total of 47 Patients with malignant tumors in the DePartment of Nutrition and Metabolism TheraPy,Anhui Cancer HosPital from October 2020 to August 2021 were selected..The exPerimental grouP(31 cases):D-ribose+nutritional suPPort theraPy + antitumor drug theraPy,and the control grouP(16 cases):nutritional suPPort theraPy + antitumor drug theraPy.The exPerimental grouP:BFI table(4-6 Points)was used for oral D-ribose 10 ml/time,BID,and BFI table(7-10 Points)was used for oral D-ribose 10 ml/time,TID.The end Points of the study were the changes of BFI,PFS-R,SDS,SAS,PG-SGA,ECOG,and BMI.The database was established and the statistical software SPSS 22 was used for data analysis.The enumeration data were exPressed as Percentage.Chi square test was used for inter grouP comParative analysis.The measurement data were exPressed as(x± s).The comParison between grouPs was Performed by t test.The measurement data of rePeated measurement were analyzed by rePeated measurement variance analysis.The significance level was P<0.05.Results:A total of 47 samPles were included in this study,and there was no significant statistical difference in demograPhic data and clinical characteristics between the two grouPs(P>0.05).The observation results during the exPeriment are as follows:Research Background:Cancer related fatigue(CRF)is one of the most common and severe subjective accomPanying symPtoms of tumor Patients,with an incidence of 59% to 99% [1-2].About 65%-100% receiving chemotheraPy and 82%-96% of tumor Patients receiving radiotheraPy will exPerience varying degrees of CRF [3].CRF can run through the entire Process of tumor occurrence,develoPment,treatment and Prognosis [4],which seriously affects the treatment comPliance and quality of life of Patients.CRF not only It brings Physical and Psychological burdens to Patients,and also brings treatment Problems to clinicians.1.BFI score and PFS-R score : BFI score and PFS-R score in the D-ribose nutritional suPPort group were significantly imProved before and after treatment(P<0.001).At 1 week,2 weeks and 3 weeks of treatment,BFI and PFS-R scores in the experimental grouP were lower than those in the control grouP at the same Period(P<0.05).The BFI and PFS-R scores in the D-ribose nutritional suPPort grouP decreased most within 2 weeks before treatment.2.PFS-R four dimensions score : the two grouPs before and after treatment in behavior,emotion,Perception difference was statistically significant(P>0.05).3.SAS and SDS scores : There was no significant difference in SAS and SDS scores between the two grouPs before and after treatment(P>0.05),but the SAS and SDS scores in the D-ribose nutritional suPPort grouP were statistically significant in time effect(P<0.001).4.ECOG score,PG-SGA score and BMI index : There was no significant statistical difference in ECOG score,PG-SGA score and BMI index between the two grouPs before and after treatment(P>0.05).Conclusion: Nutritional suPPort containing D-ribose can significantly imProve the status of anxiety and depression in Patients with malnutrition CRF within 3 weeks. |
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