Clinical Study Of Xintongtai In The Treatment Of Stable Angina Pectoris With Qi Stagnation And Blood Stasis Syndrome And Myocardial Energy Metabolism

Objective:To study the clinical effect of Xintongtai on stable angina pectoris(SAP)with qistagnation and blood stasis syndrome(QSBSS)and explore the possible mechanism of Xintongtai in treating SAP with QSBSS,so as to provide a new prescription for the treatment of SAP with QSBSS.Methods:80 patients of SAP with QSBSS were randomly divided into observation group(40 cases)and control group(40 cases).The observation group was treated with Xintongtai and the standard treatment of western medicine,while the control group was treated with trimet azidine hydrochloride and the standard treatment of western medicine.After 4 weeks of treatment,the clinical efficacy of the two groups was evaluated before and after treatment,including the frequency,duration and efficacy of angina pectoris,electrocardiogram efficacy,nitroglycerin usage,traditional chinese medicine(TCM) syndrome score and efficacy.Finally,the myocardial energy expenditure(MEE)and free fatty acid(FFA)content of two groups of patients were detected before and after treatment.Results:1.By comparing the patients of SAP with QSBSS before and after treatment,it was found that both the observation group treated with Xintongtai and the standard treatment of western medicine and the control group treated with trimetazidine hydrochl oride and the standard treatment of western medicine can decrease the frequency,duration of angina pectoris,and TCM syndrome scores,improve nitroglycerin stop minusrate,and effectively improve the angina pectoris and electrocardiogram and TCM syndrome(P < 0.01).The curative effect of observation group was significantly better than that of control group(P < 0.01).2.Both the observation group treated with Xintongtai and the standard treatment of western medicine and the control group treated with trimetazidine hydrochloride and the standard treatment of western medicine had the effect of decreasing MEE and FFA(P < 0.01),and the decrease was more obvious in the observation group(P < 0.01).Conclusion:Xintongtai has a significant effect on patients of SAP with QSBSS,the mechanism of which may be related to the substantial decrease of MEE and FFA.