| Objective:Adopt the method of retrospective study,the kidney blood fetus party for in vitro fertilization-embryo transfer（IVF-ET）threatened abortion with postoperative uterine hemorrhage in patients with clinical symptoms,TCM syndrome integral,serum human chorionic gonadotropin（beta HCG）and progesterone（P）,blood clots elastic graph and the area of the uterine cavity hemorrhage and the effect of multiple objective evaluation of curative effect and security,To provide a safe and effective basis for diagnosis and treatment of threatened abortion complicated with intrauterine hematocele after IVF-ET.Methods:A total of 115 patients admitted to The department of Gynecology of Ningbo Hospital of Traditional Chinese Medicine from January 2019 to December 2021 who were clearly diagnosed as threatened abortion in early pregnancy after IVF-ET combined with intrauterine hematocele belonging to kidney deficiency and blood stasis type were collected by retrospective study and pre-designed inclusion and exclusion criteria.The patients were divided into observation group and control group according to whether the prescription of tonifying kidney,removing stasis and calming fetus was used.Control group received conventional western medicine treatment,a total of 50 cases,observation group on this basis,65 cases were given oral tonifying kidney huayu fetal formula.TCM syndrome score,serumβ-HCG,P,thrombolysis diagram（R,K,α Angle,MA,CI）,intrauterine hematocele area and clinical efficacy were observed before and after treatment in the two groups.Clinical efficacy and safety evaluation were observed after treatment in the two groups,and statistical analysis and comparison were made between the indicators before and after treatment.Results:1.Age before treatment,BMI index,infertility years,days of menopause,menstrual conditions（period,period,quantity,color,concomitant symptoms）,previous abortion,past IVF-ET of patients in both groups There were no statistically significant differences in the number of failed cycles,number of transplanted embryos,TCM syndrome score before treatment,serum β-HCG,P,thrombus elastic graph（R,K,α Angle,MA,CI）,and intrauterine hemoperfusion area under B-ultrasound（P>0.05）.2.Clinical efficacy:in the control group of 50 patients,1 case was cured,23 cases were marked,10 cases were effective,16 cases were ineffective,the total effective rate was 68.00%;Among the 65 patients in the observation group,9 cases were cured,36 cases were effective,13 cases were effective and 7 cases were ineffective.The total effective rate was 89.23%.The effective rate of the observation group（89.23%）was significantly better than that of the control group（68.00%）,and the difference was statistically significant（P<0.05）.3.TCM syndrome score:the TCM syndrome score of the two groups after treatment was significantly reduced（P<0.05）.The score of the observation group after treatment was 5.63±4.47,which was significantly lower than that of the control group（8.36±5.04）（P<0.05）.4.Serum β-HCG and P:the levels of serum β-HCG and P in 2 groups were significantly increased after treatment（P<0.05）,and the increased levels in observation group were significantly better than control group.There are significant differences（P<0.05）.5.Thrombus elasticity diagram:After treatment,R value and K value were significantly increased（P<0.05）,MA,α Angle and CI were significantly decreased（P<0.05）.After treatment,MA,α Angle and CI in the observation group were lower than those in the control group（P<0.05）,while R and K values were higher than those in the control group（P<0.05）.6.Area of intrauterine blood accumulation:after treatment,the area of intrauterine blood accumulation in both groups was reduced compared with that before treatment（P<0.05）,and the area of intrauterine blood accumulation in observation group was reduced more significantly than that in control group,the difference was statistically significant（P<0.05）.7.There were no adverse reactions in both groups during treatment.Conclusion:Bushen Huayu Antai Prescription combined with progesterone is a safe and effective method for the treatment of threatened abortion complicated with intrauterine hemoperitoneum after IVF-ET,which can effectively promote the absorption of intrauterine hemoperitoneum,relieve the associated clinical symptoms,and improve the treatment efficiency without obvious side effects. |
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