| Objective: Pulmonary hypertension(PH)is one of the common complications in chronic obstructive pulmonary disease(COPD).The study aimed to evaluate the predicting ability of N-terminal probrain natriuretic peptide(NT-proBNP)in patients with AECOPD-PH and its relationship with the severity of PH.Methods: A large retrospective case-controlled study(n=1072)was performed in the First Affiliated Hospital of Xinjiang Medical University from January 2018 to December 2020,and patients were divided into stable COPD(n=178),AECOPD(n=688)and AECOPD-PH group(n=206).Results: In unadjusted analysis and PSM(model 1,2,3),red cell distribution width(RDW),total bilirubin(TBIL),and NT-proBNP were higher in patients with AECOPD-PH than those in AECOPD group.Logistic regression analysis showed that RDW had no statistic difference.When the range of NT-proBNP was 271-1165pg/m L(OR: 0.293;95%CI:0.184-0.467;P<0.001)and NT-proBNP>1165pg/m L(OR: 0.559;95%CI: 0.338-0.926;P=0.024),the morbidity risk of PH in AECOPD patients was increased,so did TBIL.In receiver operating characteristic(ROC)curves,at the cut-off value of NT-proBNP was175.14pg/m L,AUC was 0.651(P<0.001),which was better than TBIL(AUC: 0.590,P<0.001).As for the results of rank correlation analysis,TBIL had no significant difference,and NT-proBNP had a weak correlation with severity of PH with AECOPD(r=0.299,P=0.001).Conclusion: Our findings suggest that NT-proBNP has a diagnostic efficacy in AECOPD-PH and NT-proBNP has a weak correlation with severity of PH with AECOPD. |
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