To Explore The Potential Risk Factors For Frequent Acute Exacerbations In Hospitalized Patients With Chronic Obstructive Pulmonary Disease

Objective: To explore the potential risk factors of frequent acute exacerbation in hospitalized patients with chronic obstructive pulmonary disease,we analysed the clinical features of patients with acute exacerbation of chronic obstructive pulmonary disease,so as to provide the value for individualized treatment of stable chronic obstructive pulmonary disease.Methods: A retrospective analysis was made on the medical records of the First Affiliated Hospital of Jinan University from June 1,2015 to May 31,2018,which includes the diagnosis of acute exacerbation of chronic obstructive pulmonary disease(ICD: J44.100).And according to the Spain COPD guide made in 2017,those medical records were divided into frequent exacerbations group(FE)and infrequent exacerbation group(i FE).The relevant data of AECOPD hospitalized patients,such as their general information,lung function,comorbidities,laboratory results,and medication status etc,were collected for making detailed analysis based on the statistical methods,including linear correlation,univariate analysis and multivariate logistic regression analysis and other statistical methods,the aim of which was to explore the potential risk factors for acute exacerbations of hospitalization in patients with COPD.Results: 1.The number of hospitalizations in previous year for AECOPD hospitalized patients was positively correlated with peripheral blood eosinophil(EOS),the charlson comorbidity index(CCI),and the modified Medical British Research Council(m MRC);2.Multivariate regression analysis showed that EOS% ≥ 2% in peripheral blood[OR=1.992,95% CI(1.196~3.316),P=0.008],m MRC [OR= 1.346,95% CI(1.050~1.726),P= 0.019],CCI [OR= 1.458,95% CI(1.202~1.767),P=0.000] were the independent risk factors for patients with frequent acute exacerbations of AECOPD.3.Using blood EOS%≥2%,CCI and m MRC,the three risk factors for ROC curve prediction of frequent acute exacerbations AECOPD hospitalized patients,there was the sensitivity of 67.4%,specificity of 52.7%,the area under the curve was 0.668.Conclusion: Peripheral blood EOS% ≥ 2%,CCI and m MRC are the independent risk factors for frequent acute exacerbations in hospitalized patients with chronic obstructive pulmonary disease.