Study On The Relationship Between Nonalcoholic Fatty Liver Disease And Blood Stasis Syndrome Based On The Changes Of Hemorheology Indexes

Research Objective: To explore the relationship between nonalcoholic fatty liver disease and blood stasis syndrome based on the changes of hemorheology index,and to provide objective theoretical and data basis for clinical treatment.Research methods:1.According to the cross-sectional survey and research method,design the questionnaire.A total of 178 patients who met the inclusion criteria from December2018 to November 2020 in the First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine and the outpatient department of Yunnan University of Traditional Chinese Medicine were collected and divided into mild fatty liver(136cases)and moderate fatty liver(30 cases),severe fatty liver(12 cases),and collected basic information,lifestyle,four-diagnosis information of traditional Chinese medicine,physical examination and blood routine,liver function,blood lipids,hemorheology,abdominal color Doppler ultrasoundrelevant information.2.According to the patient’s symptoms and signs,combined with tongue and pulse condition and other information,the blood stasis syndrome score of patients with nonalcoholic fatty liver disease was calculated according to the "blood stasis syndrome symptom classification quantitative table".3.Spss25.0 statistical analysis was used to collect data,chi square analysis was used to analyze the relationship between age,gender and BMI,analysis of variance was used to study the changes of red blood cell related indexes,liver function indexes,blood lipid indexes and hemorheology indexes among the groups,Pearson correlation analysis was used to study the correlation between the laboratory indexes observed by NAFLD patients and the symptom score of blood stasis syndrome,and the test standard was established(P < 0.05)for a significant difference,with statistical significance.Research results:Analysis of general data of patients with nonalcoholic fatty liver disease1.There was no significant difference in age of onset(P > 0.05).2.In this study,the proportion of female sex is greater than that of male in BMI< 24;the proportion of male is greater than that of female in BMI ≥ 24.The mean BMI of male patients was higher than that of female patients.There was significant difference(P < 0.05).3.With the aggravation of fatty liver,body mass index increased.Mild fatty liver< moderate fatty liver < severe fatty liver(P < 0.05).Distribution of clinical data of patients with nonalcoholic fatty liver disease:In this study,178 patients were classified according to the degree of abdominal color Doppler ultrasound.With the aggravation of fatty liver,the laboratory indexes of blood routine(red blood cells,hemoglobin),liver function(alanine aminotransferase,aspartate aminotransferase,cholinesterase),blood rheology(whole blood viscosity,plasma viscosity,whole blood low shear relative index,erythrocyte aggregation index)were observed There were significant differences in the changes of whole blood low shear reduced viscosity,whole blood high shear reduced viscosity,erythrocyte rigidity index and erythrocyte deformation index(TK)among the groups(P < 0.05).Statistical analysis of blood stasis syndrome symptom scores in patients with non-alcoholic fatty liver diseaseComparison of the average blood rheological index of patients with non-alcoholic fatty liver disease with the normal reference range,whole blood viscosity,plasma viscosity,whole blood high and low shear relative index,red blood cell aggregation index,whole blood high and low shear reduced viscosity,red blood cell rigidity index Higher than the normal level(P<0.01),the red blood cell deformation index tk is lower than the normal level(P<0.01).Correlation analysis between laboratory indexes and symptom score of blood stasis syndrome in patients with nonalcoholic fatty liver disease1.the blood routine related indexes: red blood cells,hemoglobin,platelet hematocrit were positively correlated with the symptom score of blood stasis syndrome(P < 0.05).2.the liver function related indexes: aspartate aminotransferase,y-glutamyl aminotransferase and cholinesterase were positively correlated with the symptom score of blood stasis syndrome(P < 0.05).3.the blood lipid related indexes: the high density lipoprotein cholesterol index was positively correlated with the symptom score of blood stasis syndrome(P <0.05).4.hemorheology indexes: whole blood viscosity,plasma viscosity,hematocrit,whole blood high cut relative index,whole blood low cut relative index,blood sedimentation equation K value,red blood cell aggregation index,whole blood low cut reduction viscosity,whole blood high cut reduction viscosity,red blood cell rigidity index and blood stasis syndrome symptom integral were positively correlated(P < 0.05).The RBC deformation index TK was negatively correlated with the symptom score of blood stasis syndrome(P < 0.05).Research conclusions:1.Nonalcoholic fatty liver disease is closely related to blood stasis syndrome.The degree of blood stasis is aggravated with the aggravation of fatty liver disease.Patients with nonalcoholic fatty liver disease have blood stasis syndrome in the early stage.When there are no obvious clinical symptoms in the early stage of nonalcoholic fatty liver disease,the method of promoting blood circulation and removing blood stasis is helpful to the treatment of the disease.2.The quantitative score of blood stasis syndrome in patients with NAFLD is closely related to some indexes of hemorheology,which can be used as one of the objective indexes for the diagnosis of blood stasis syndrome in NAFLD.