| Objective To uses professor zhang liangying’s experience prescription combined with TCM packet to treat the liver stagnation and spittoon congealment mammary lump,observes the clinical effect of using internal and external combined treatment to treat the mammary lump,and explores a better TCM treatment method to this disease.Methods 90 cases of patients who met the inclusion criteria were collected and randomly divided into three groups.Treatment group(n=30)using oral Xiaopiyin combine TCM packet;Control group(A)(n=30)only took Xiaopi decoction orally;Control group(B)(n=30)was only using TCM packet.After 3 courses of treatment,clinical primary symptoms,secondary symptoms,breast ultrasound and safety indexes were observed before and after treatment.SPSS25.0 statistical software was used to analyze and process the data.Results1.Before treatment,age,course of disease,primary symptom,secondary syndrome,and size of B-ultrasound breast nodules of the three groups were compared(P>0.05),and the differences were not statistically significant,but comparable.2.Overall efficacy after treatment: the treatment group was better than the two control groups in improving the efficacy of primary symptoms(P<0.05),and there was no statistical difference between the two control groups(P>0.05);The treatment group and control group A were better than control group B(P<0.01)in improving the efficacy of the three groups,and there was no statistical difference between the treatment group and control group A(P>0.05).The treatment group was superior to the two control groups in improving the comprehensive efficacy of the three groups(P<0.05),and there was no statistical difference between the two control groups(P>0.05).3.Symptom score(1)Main symptom score: The total symptom score of the three groups was significantly lower after treatment than before treatment(P<0.01).The clinical efficacy of the treatment group in improving the main symptom was better than that of the two control groups(P<0.05),and there was no statistical difference between the two control groups(P>0.05).After treatment,symptom scores of the three groups were significantly lower than those before treatment(P<0.05).In terms of improving breast pain,mass range and hardness,the treatment group was better than control group A(P<0.05).The improvement of breast pain and mass range in treatment group was better than that in control group B(P<0.05).In improving the hardness of breast lumps,control group B was better than control group A(P<0.05).There was no statistical difference in reducing breast mass size between treatment group,control group A and control group B(P>0.05).(2)Score of secondary symptoms: The total score of secondary symptoms in the three groups after treatment was significantly lower than that before treatment(P<0.01).Treatment group and control group A were better than control group B in improving secondary symptoms(P<0.05),and there was no statistical difference between treatment group and control group A(P>0.05).After treatment times disease symptom integral in three group were significantly lower than before treatment(P<0.05),in improving the good depression irritability,chest stuffy,upset,mouth pain,insomnia and dreaminess,often the new stay,menstrual quantity,colors,and the line of abdominal pain,defecate in the treatment group and control group were superior to control group B(P<0.05),no statistical difference between treatment group and control group A(P>0.05).4.The size of breast B-ultrasound nodules: after treatment,the size of nodules in the three groups was significantly reduced compared with that before treatment(P<0.01),but there was no statistical difference between the treatment group,control group A and control group B(P>0.05).5.Follow-up: 1 month after the end of treatment,the recurrence rate of the three groups was lower than that of the two control groups(P<0.05),and there was no statistical difference between the two control groups(P>0.05).6.Safety and adverse drug reactions: no abnormalities were observed before and after the treatment for safety indicators.Three patients developed mild skin allergy,and continued to take the drug 3 days after withdrawal until the end of the course of treatment without any special adverse reactions.Therefore,it is suggested that the three treatment methods are safe and have no obvious adverse reactions.ConclusionThrough the research of this subject,the following conclusions are drawn:1.Xiaopi decoction combined with TCM packet group,Xiaopi decoction group and TCM packet group were all effective in the treatment of patients with liver depression and spittoon condensation type milk febrile.The curative effect of Xiaopi decoction combined with TCM packet group was better than that of Xiaopi decoction group and TCM packet group.2.In terms of improving the main symptoms,the efficacy of Xiaopi decoction combined with TCM packet group was superior to that of Xiaopi decoction group and TCM packet group respectively.The efficacy of Xiaopi decoction combined with TCM packet group and Xiaopi decoction group was better than that of TCM packet group in improving secondary symptoms.3.The size of B-ultrasound breast nodules was significantly reduced after treatment with the three methods.4.No obvious adverse reactions occurred in the three methods,and the safety was high.Professor zhang liangying’s experienced that prescription xiaopi decoction combined with traditional TCM packet in the treatment of mammary lump with liver depression and cuspidor is safe and worthy of clinical promotion and application. |
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