| Objective: To investigate the relationship between blood lipid level,blood coagulation function and the onset,progression and outcome of sudden hearing loss(SHL)by retrospective analysis the blood lipid and coagulation indexes.Methods: A total of 480 patients with SHL diagnosed in the Department of Otolaryngology of Hebei Provincial People’s Hospital from January 2017 to December 2020 were selected as the SHL group,and 100 patients with no history of inner and middle ear diseases in the same period were selected as the control group.The general information,related examinations and test results of all patients were collected through the electronic medical record system,and the obtained data were statistically analyzed.Results:1.The levels of total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL),very low density lipoprotein(VLDL)and apolipoprotein B(Apo B)in the sudden deafness group were higher than those in the control group,and the difference between the two groups was statistically significant(P < 0.05).2.The levels of TG and VLDL in male SHL patients were higher than those in female,and the levels of high-density lipoprotein(HDL),apolipoprotein A1(Apo A1),fibrinogen(Fib)and prothrombin time(PT)were lower than those in female patients,with statistical significance(P < 0.05).The hearing types of male patients were mainly full frequency and total deafness type,while female patients were mainly full frequency and reduced low frequency type,and the difference between the two groups was statistically significant(P < 0.05).There was no significant difference in therapeutic effect distribution between the two groups(P > 0.05).3.There were statistically significant differences in the levels of Apo A1/Apo B and activated partial thromboplastin time(APTT)among different types of SHL groups(P < 0.05).Apo A1/Apo B was the highest in the low-frequency decreasing type,but there was no statistical significance in pairwise comparison between each group.The level of APTT in patients with low frequency decline was higher than that in patients with total deafness,and the difference was statistically significant(P < 0.05).The age of full frequency and full deafness type SHL patients was higher than that of low frequency and high frequency type,and the difference was statistically significant(P <0.05).Low frequency SHL patients had the best curative effect,followed by full frequency type,high frequency type and total deafness type,and the distribution difference among the four groups was statistically significant(P <0.05).4.There was no significant difference in blood lipid level and coagulation function among SHL groups with different therapeutic effects(P > 0.05).The majority of SHL patients with hypertension and/or diabetes were invalid,while the majority of SHL patients without underlying diseases were cured,with statistically significant difference in the proportion of curative effect distribution between groups(P < 0.05).Conclusions:1.Hyperlipidemia may be one of the pathogenesis factors of SHL;The pathogenesis of low frequency SHL patients is different from that of total deafness patients.Old age,blood lipid level and abnormal blood coagulation function may be the influencing factors of total deafness patients.2.The prognosis of SHL patients was related to hearing type,hypertension/diabetes mellitus or not,and was not related to blood lipid level or coagulation function.3.The prognosis of female SHL patients may be related to other factors other than the type of hearing loss,blood lipid level,coagulation function and which need further study. |
