| Objective:The exploration of the differences in clinical features and relevant laboratory indexes of hearing loss in patients with full-frequency sudden hearing loss aimed in providing evidence for individualized therapeutic schemes.Methods:A retrospective analysis was performed on the clinical data of 123 patients with full-frequency sudden hearing loss.The first part of the study was to observe the differences between the flat-descending-deaf group and total-deaf group in terms of clinical characteristics such as,gender,age,ear side,visit time,associated symptoms(tinnitus,dizziness)and underlying diseases(hypertension,diabetes),as well as related laboratory indicators(platelets,coagulation series,D-dimer,blood lipids,hemorheology);The second part of the study compared the differences in the laboratory parameters(platelets,coagulation series,D-dimer,blood lipids,and hemorheology)between the mildly flat-descending-deaf group and the severely flat-descending-deaf group.SPSS23.0 statistical software was used in analyzing the data and the frequency was analyzed by Chi-square test.The count data(continuous type)was first tested by Shapiro-Wilk(W test)for normality.The data with normal distribution was described by ` x±s and two independent sample t-tests were used for comparison between groups.Medians(interquartile range)were used for data that did not meet normality,and non-parametricrank sum tests were used for comparison between groups.All results were statistically significant at P<0.05.Results:1.Among 51 flat descending cases,the ratio of male and female was 2.401: 1,72;among 72 total hearing loss cases,the ratio of men and women ratio was 1.058:1(P<0.05).Among two groups of patients,the majority received treatment within 7 days,among whom 66.7% were flat descending population,and 83.3% were total hearing loss population(P<0.05).Flat descending population with dizziness only accounted for 35.3%while this figure was up to 70.8% when it came to total hearing loss patients(P<0.01).Two groups showed no differences in age,ear side,tinnitus,the original underlying diseases(hypertension,diabetes).2.The total hearing loss population overtopped the plat descending population in PLT and PCT,while falling below the plat descending population in APTT.The differences were statistically significant(P<0.05).Two groups showed no differences in other indicators of platelet and coagulation series and laboratory data of D-dimer,blood lipids,hemorheology.3.The levels of lipoprotein(a)in patients with moderate flat descending were significantly lower than those in patients with severe flat descent(P<0.05).There were no statistically significant differences on the remaining indicators between the moderate and severe.Conclusion:Compared with flat descending sudden hearing loss,sudden total hearing loss more frequently happened to females who also were accompanied by dizziness.The treatment rate within 7 days was high and the patients with hypercoagulable state accounted for a higher proportion,which suggests that individualized treatment should be based onthrombolysis.In the study,Lipoprotein(a)was positively correlated with the degree of hearing loss in flat descending sudden hearing loss,meaning drugs that reduce Lipoprotein(a)can be used in the treatment.Futhermore,Lipoprotein(a)could also be used as indicator of prognosis. |
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