| Objective: By comparing the levels of peripheral blood indicators between patients with sudden deafness and the control group,the expression of blood coagulation and blood lipid-related indicators in the occurrence,development and prognosis of SHL between different groups was analyzed,and the predictive value of the apo B/apo A1 in the occurrence and prognosis of sudden deafness;by comparing the levels of various blood coagulation and blood lipid-related indicators among various hearing loss groups of sudden deafness patients,analyze the influence factors of the different clinical manifestations type of sudden deafness patients;by comparing the differences of various peripheral blood indicators in different therapeutic groups,studying the factors affecting the prognosis of sudden deafness,and looking for prognostic indicators with predictive value.Method: Sixty-three patients who unilateral sudden deafness in the Department of Otorhinolaryngology were collected as the experimental group From August 2019 to January 2020,forty patients with non-ear diseases were selected to be the contrast group during the same period.All patients in the group underwent electrical audiometry,blood routine,blood coagulation and blood lipid testing before treatment,and related medical history data were collected.The treatment plan for patients with sudden deafness is oral steroid hormones(without contraindications)+ improve circulation +nutrient nerves.After 14 days,electrical audiometry will be performed to calculate the average hearing threshold changes in the frequency range of the patients with sudden deafness,and compared the level of blood indicators between the valid group and invalid group to explore the correlation between blood coagulation,blood lipids and sudden deafness,different clinical characteristics and prognosis.Result: 1.PLT,APTT,HDL-C,apo A1,apo B/apo A1,and the ATH index in the sudden deafness group were 246.17±56.59×10^9/L,35.05±3.25 s,1.22(1.05~1.40)mmol/L,1.18(1.07~1.33)g/L,0.79±0.20,2.22(1.63~3.00),the control group were 210.58±53.57×10^9/L,36.43±3.19 s,1.35(1.19~1.62)mmol/L,1.43(1.28~1.52)g/L,0.65±0.14,1.57(1.17~2.45).PLT,APTT,HDL-C,apo A1,apo B/apo A1 and the ATH index level between sudden deafness group and control group was significantly different(P<0.05),while gender,age,PT,FIB,TT,TG,TC,LDL-C,and apo B were not significantly different between the sudden deafness group and the control group(P>0.05).Based on the differential expression of apo B/apo A1 and the ATH index between the control group and SHL group,the ROC curve was made and the AUC was calculated to be 0.726 and 0.661(P<0.05),suggesting that apo B/apo A1 and the ATH index have a certain predictive effect on the occurrence of SHL;2.PT,TT and LDL-C of the moderate hearing loss group were 12.30(11.90~12.70)s,15.70(15.30~16.30)s,2.69±0.68 mmol/L,the severe hearing loss group was 12.45(12.20~13.18)s,16.50(15.90~17.08)s,3.13±0.76mmol/L.The PT,TT and LDL-C between the moderate hearing loss group and the severe hearing loss group has a significant difference(P<0.05),and there is no significant difference in other indicators between the moderate hearing loss group and the severe hearing loss group(P>0.05);3.Age in low frequency,high frequency,flat and the total deaf hearing loss group was 36.00±9.95 years old,42.76±12.72 years old,50.54±10.26 years old,47.73±14.08 years old,and PT among different hearing loss groups were 12.34±0.55 s,12.44±0.58 s,12.16±0.55 s,12.92±0.95 s.TT in different hearing loss groups are 15.30(14.80~15.60)s,16.00(15.40~16.35)s,15.85(15.60~16.38)s,17.00(16.10~17.30)s.There are significant differences in age,PT and TT levels between the loss type groups(P<0.05),while the other indicators have no significant differences between the different hearing loss types(P>0.05);4.The effective rates of treatment in Low-frequency and high-frequency hearing loss groups were 90.9% and 17.6%,the age,course of disease,apo B and apo B/apo A1 of the effective group were 39.90±11.51 years old,4.00(2.00~7.00)days,0.41±0.13×10^9/L,0.84(0.74~1.01)g/L,0.74±0.18,the ineffective group were 50.75±11.27 years old,14.00(7.00~28.75)days,0.35±0.13×10^9/L,1.02(0.85~1.12)g/ L,0.84±0.22.The type of hearing loss,age,course of disease,apo B and apo B/apo A1 have significant differences among different efficacy groups(P<0.05),and the other indicators have no statistically significant differences among different efficacy groups(P>0.05).The ROC curve was made for the difference between apo B/apo A1 in different groups,AUC=0.658,P<0.05,apo B/apo A1 has a certain value in predicting the prognosis of SHL.The mean values of apo B/apo A1 in the SHL group,the control group,the effective group and the ineffective group were 0.79±0.20,0.65±0.14,0.74±0.18,0.84±0.22,indicating that apo B/apo A1 have a significant difference between different curative effect groups and the control group and the SHL group(P<005),and the mean value of apo B/apo A1 showed an upward trend among the control group,the effective group and the ineffective group.Conclusion: 1.Apo B/apo A1 can identify abnormal lipid metabolism in the initial stage when the conventional lipid index is still normal,and the occurrence of SHL and Effective evaluation of prognosis.2.Apo B/apo A1 showed a rising trend among the control group,the effective group and the ineffective group,indicating that the improvement of abnormal lipid metabolism can not only reduce the risk of SHL,but also effectively improve the prognosis of SHL patients.3.The occurrence of SHL is related to abnormal blood coagulation status and lipid metabolism disorders;4.SHL with a young age,short course of disease,without lipid metabolism disorder,and low-frequency hearing loss has a better prognosis than other types of SHL. |
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