Meta-Analysis For Clinical Efficacy Of Knee Osteoarthritis With Low Intensity Pulsed Ultrasound

Objective: To systematically evaluate the effects of low intensity pulsed ultrasound on pain,physical function and safety and safety in patients with knee Osteoarthritis.Methods: This systematic reviews was searched on CNKI,Wan Fang,VIP,Cochrane Library,Pub Med and EMBase from inception to 31 December,2020.The inclusion criteria were developed based on the Prisma principle to search the randomized controlled trial of that compared low intensity pulsed ultrasound with a sham or no intervention in patients with osteoarthritis of the knee.All the documents were managed with the End Note software.Then we evaluated the quality of the included literature according to the Cochrane Handbook bias risk assessment tool and analyzed the data using the Rev Man 5.3 software.Result: A total of 10 randomized controlled trial were included with a total of712 patients.The Meta-analysis showed us that low intensity pulsed ultrasound therapy could relieve the pain score of patients with knee osteoarthritis [MD =-0.88,95%CI(-1.49,-0.27);Z =2.82,P =0.005],improve the WOMAC score,Lequesne score and Lysholm score with significant differences[MD =-5.04,95%CI(-7.35,-2.73);Z =4.28,P<0.0001]、 [MD =-1.41,95%CI(-2.19,-0.62);Z =3.52,P=0.0004]、 [MD =20.49,95%CI(17.06,23.91);Z =11.73,P<0.00001].In terms of safety,no occurrence of adverse events caused by low intensity pulsed ultrasound was reported in any trial.Conclusion: We came to a conclusion that low intensity pulsed ultrasound used to treat patients with knee osteoarthritis has a positive effect on relieving their pain and improving knee joint function.It could be a safe treatment and considered in the rehabilitation programs for patients with knee osteoarthritis.