Preliminarily Analyze The Short-term Clinical Therapeutic Effect Of Low-intensity Pulsed Ultrasound, Intra-articular Injection Of Sodium Hyaluronate And These Two Methods Combined On The Mild And Moderate Knee Osteoarthritis

ObjectivesThis study is to preliminarily analyze the short-term clinical therapeuticeffect of low-intensity pulsed ultrasound, intra-articular injection of sodiumhyaluronate and these two methods combined on the mild and moderateknee osteoarthritis.MethodsDuring January2012to March2013, totally108mild and moderatesingle knee osteoarthritis orthopedic outpatients of the second affiliatedhospital of Chongqing medical university were enrolled in the clinicaltrail.They were randomly divided into three groups:Low-intensity pulsedultrasound combined with intra-articular injection of sodium hyaluronatetreatment group (group A,36cases), low-intensity pulsed ultrasound treatment group (group B,38cases) and intra-articular injection of sodiumhyaluronate treatment group (group C,34cases).Each group received thecorresponding treatment for5weeks.During the clinical trial, all patients’treatment was routinely recorded. After completing the clinical study, thetreatment compliance and the incidence of clinical adverse events werecalculated and compared. Meanwhile, the knee pain VAS score and clinicalfunctional Lequence score of three groups before and after clinical trial wereevaluated and compared. Moreover, the VAS score efficacy index andLequence score efficacy index of three groups were calculated andcompared. At last, the overall VAS score treatment effective rates andLequence score treatment effective rates of three groups were separatelycalculated.Results1. The treatment records and basic information of patients: Totally18patients including6patients in group A,8patients in group B and4patientsin group C withdrew from this clinical research because of some personalreasons.90patients including30patients in each group completed theclinical trial. The treatment compliance of three groups were83.33%,78.95%and88.24%respectively. there was no statistical differencebetween each group. All patients’ basic information of three groupsincluding age, gender, duration and X-ray stages was no statistical difference.Among the90patients, totally7patients including3patients in group A and 4patients in group C appeared different mild clinical adverse events duringthe intra-articular injection of sodium hyaluronate treatment. Contrarily,there was no any clinical adverse events happened during the low-intensitypulsed ultrasound treatment. Three groups’ incidence of clinical adverseevents were10.00%,0.00%and13.33%respectively. Compared with groupB and group C, the incidence of group A were no statistical difference.Meanwhile, the incidence of group C were statistically higher than group B.2. The short-term treatment efficacy of relieving knee pain: Before thetreatment, the knee pain VAS score of three groups had no statisticaldifference. However, after5weeks treatment, all the VAS score werestatistically decreased. Group A declined by2.80+0.81, group B fell by1.97+0.56,and group C dropped down2.07+0.69. Compared with group Band group C, the VAS score changing value of group A had statisticaldifference. While group B compared with group C, the VAS score changingvalue were no statistical difference. The VAS score efficacy index of threegroups were0.50+0.15,0.39+0.15and0.40+0.15respectively, the VASscore efficacy index of group A were statistically higher than other twogroups. Meanwhile, compared group B with group C, the VAS scoreefficacy index had no statistical difference. The overall VAS score effectiverates of three groups were83.33%,80.00%and76.67%respectively.3. The short-team treatment efficacy of improving the knee clinicalfunction: Before the treatment, the knee clinical functional Lequence score of three groups had no statistical difference. However, after5weekstreatment, the Lequence score of all three groups were statisticallydecreased. Group A dropped down3.53+0.82, group B fell by2.83+0.65and group C declined by2.63+0.62. Group A compared with group B andgroup C, the Lequence score changing value had statistical difference, whilethe Lequence score changing value of group B and group C were nosignificant statistical difference. The Lequence score efficacy index of threegroups were0.53+0.19,0.42+0.16and0.41+0.17respectively, theLequence score efficacy index of Group A were statistically higher thangroup B and group C. Meanwhile, the Lequence score efficacy index ofgroup B and group C had no statistical difference. The overall Lequencescore treatment effective rates of three groups were86.67%,83.33%and80.00%respectively.ConclusionsDuring the clinical trail, although the incidence of clinical adverseevents are statistically higher than Low-intensity pulsed ultrasound,thesetwo methods are still safe and effective with good treatment compliance andoutstanding short-term efficacy on treating the mild and moderate kneeosteoarthritis, could significantly relieve the knee pain and improve the kneefunction. Moreover, compared with the single treatment, low-intensitypulsed ultrasound combined with intra-articular injection sodiumhyaluronate may has some certain synergic effect, has better short-term efficacy of alleviating the knee pain and improving the knee function whentreating the mild and moderate knee osteoarthritis without influencing thetreatment compliance nor increasing the treatment risk.