| Objective:To observe the clinical efficacy and safety of Shujuan Tongluo Decoction in the treatment of cerebral infarction convalescent patients with phlegm-stasis collateral-type muscle tension increase,and to provide the basis for clinical application.Methods:64 cases of cerebral infarction convalescent patients with increased muscle tension of phlegm and blood stasis type were randomly divided into treatment group and control group.The treatment group was treated with Shujuan Tongluo Decoction(200ml/ time,twice/day,warm in the morning and evening after meals);The control group received Baclofen tablets(initial dose was 5mg/ time,3 times a day,and increased by 5mg/ time every 3 days until the maintenance dose was 25mg/ time).The treatment lasted for 4 weeks.Observed two groups of patients before and after treatment of TCM symptom scores,the modified Ashworth score(MAS),the simplified Fugl-Meyer movement function grade(FMA),modified Barthel index(BI)and the change of blood lipid and blood rheology indicators,on two groups of patients after treatment of TCM symptom scores,modified Ashworth score curative effect evaluation,statistical correlation method are analyzed.Results:1.Before treatment,there were no significant differences in age,gender,course of disease,TCM symptom score,MAS,FMA,BI,blood lipid and hemorheology indexes between the two groups(P>0.05),which all met the requirements of comparative analysis.2.Changes in scores,efficacy and indicators after treatment :(1)In terms of TCM symptom scores,the comparison between the treatment group and the control group showed that the TCM symptom scores in the treatment group were higher than those in the control group(P<0.05),indicating that the symptoms in the treatment group were significantly improved;The total effective rate of the treatment group was83.33%,and the total effective rate of the control group was 56.67%,indicating that the curative effect of the treatment group was better than the control group(P<0.05).(2)Compared with before treatment,the number of decreased muscle tone in the two groups increased after treatment(P<0.05),and the number of decreased muscle tone in the treatment group was more than that in the control group,indicating that the reduction of muscle tone in the treatment group was obvious.Compared with the improved Ashworth score,the effective rate of the treatment group was 86.67%,and the effective rate of the control group was 60.00%,which was better than that of the control group(P<0.05).(3)The comparison of simplified Fugl-Meyer motor function score between the treatment group and the control group showed that the motor function score of the treatment group was higher than that of the control group(P<0.05),indicating that the treatment group had a good effect on improving the motor function of the affected limb.(4)In terms of improved Barthel scores,the comparison between the treatment group and the control group showed that the difference of the scores of daily living ability in the treatment group was larger than that in the control group(P<0.05),indicating that the treatment group had a significant effect on improving the patients’ daily living ability;(5)on blood lipid comparison,two groups of patients after treatment,total cholesterol,triglyceride,LDL-C lower earlier,HDL-C level increased(P<0.05),earlier treatment group and control group comparison results show that the treatment group patients with total cholesterol,triglycerides,LDL-C,HDL-C level improved significantly(P<0.05),the treatment group in improving blood lipids index effect is better;(6)on the hemorheology indexes,two groups of patients after treatment of the whole blood viscosity,plasma viscosity,fibrinogen,platelet aggregation index were lower(P<0.05),earlier treatment group compared with control group showed decreased index of the treatment group than the control group(P<0.05),the treatment group in improving hemorheology index is better than the control group;(7)No obvious adverse reactions and toxic side effects were observed in the treatment group after taking the medicine,and the safety was good.Conclusion :(1)Shujuan Tongluo Decoction can significantly improve the clinical symptoms,effectively reduce the abnormal increase of muscle tension in the convalescent period of cerebral infarction,reduce the degree of nerve function deficit,regulate blood lipid and hemorheology,and promote the recovery of limb function.(2)Shujuan Tongluo Decoction has better efficacy than Baclofen Tablets in the treatment of phlegm-stasis collateral-type muscle tension increase in the convalescence stage of cerebral infarction,and it is safe and reliable,and has clinical application value. |
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