| Objective:This study mainly observed the curative effect and difference between the traditional Chinese medicine of tonifying qi and nourishing Yin to intervene the unstable angina pectoris of coronary heart disease after PCI and the symptomatic supportive treatment of conventional western medicine.Meanwhile,through the treatment of traditional Chinese and western medicine,the quality of life of patients after PCI was improved.Methods:In this study,72 patients who were admitted to the Department of Cardiology and Chest Hospital of the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine from January 2018 to January 2019 and who met the diagnosis of unstable angina pectoris after coronary heart disease PCI were included according to the discharge criteria,and they were randomly divided into control group and treatment group with 36 patients in each group.Western medicine routine treatment: stop using long-acting nitric acid esters drugs,angina pectoris attack can be temporarily added with short-acting nitric acid esters;Clopidogrel bisulfate tablets(Taijia)were used as antiplatelet drugs.Beta blockers,calcium antagonists,statins are not added in principle.Emotional counseling for patients,warn patients to give up smoking,alcohol,reasonable diet,so that patients understand their own conditions,can actively cooperate with treatment.The experimental group was given Tongmai Yangxin pill,40pills/time,orally twice a day,for 4 weeks.The control group was given simulated Tongmai Yangxin Pill,40 pills/time,orally taken twice a day,for 4 weeks.Baseline data of the two groups were statistically analyzed.Seattle SAQ score,TCM syndrome score and comprehensive efficacy,angina symptom score and major cardiovascular adverse events were used as efficacy observation indexes before and after treatment of Tongmai Yangxin Pill to evaluate angina symptom and TCM syndrome improvement of patients before and after treatment.Vital signs,liver function,renal function,blood routine and urine routine were used as safety evaluation indexes to evaluate the safety of Tongmai Yangxin Pill in the treatment of unstable angina pectoris after coronary heart disease PCI,and to observe whether the safety indexes were abnormal after treatment.Excel software was used to record all the data,and the database was established.IBM SPSS22.0 statistical software was used for statistical analysis.Results:1.Basic data: Statistical analysis was conducted on gender,age,BMI,vital signs,history of diabetes,hypertension,hyperlipidemia,family history of coronary heart disease,smoking history,and GRACE score between the two groups,and the results showed P > 0.05,with no statistical difference.2.Comparison of TCM syndrome scores and efficacy: after treatment,there was a significant statistical difference between the two groups(P < 0.01).The total effective rate of Tongmai Yangxin Pill group was 87.5%,and the total effective rate of simulated agent group was 55.9%,with P < 0.05.There was a statistical difference between the two groups.Further analysis of the therapeutic effect difference between the two groups showed that there was no statistical difference between the two groups in terms of cure,obvious effect and effective number(all P > 0.05),while there was a statistical difference in terms of ineffective number(P< 0.05).3.Comparison of single symptom of TCM syndrome: intra-group comparison was conducted before and after treatment between the two groups of patients,and the results showed that there were statistically significant differences in chest pain,palpitation,shortness of breath,tiredness and lazy speech,dry mouth and thirst,and spontaneous sweating(all P < 0.05).There was no significant difference in insomnia and dreaminess before and after treatment in simulated agent group(P BBB 0 0.05).Comparison of single symptom of TCM syndrome between the two groups after treatment showed that there were statistical differences in chest pain,shortness of breath,languor and lazy speech,dry mouth and thirst,insomnia and dreams(all P < 0.05),while there was no statistical difference in palpitation and spontaneous sweating between the two groups(P > 0.05).4.Comparison of angina symptom scores and efficacy: there was a statistical difference in angina symptom scores between the two groups before and after treatment(P < 0.05).After treatment,angina scores were compared between the two groups,and the results showed P <0.05,showing a statistical difference.Further inter-group comparison of the two groups showed that there was no statistical difference in the number of effective and effective patients between the two groups(all P > 0.05),while there was a statistical difference in the number of ineffective patients between the two groups(P < 0.05).Comparing the comprehensive efficacy of the two groups after treatment,the total effective rate of the Tongmai Yangxin pill group was 81.25%,and the total effective rate of the simulated agent group was 58.82%(P < 0.05),with statistical difference between the two groups.5.Seattle Angina Scale: After treatment,the differences between the two groups were compared,and the results showed statistical differences in four single dimensions,including the degree of physical activity limitation,stable state of angina pectoris,angina attack,and treatment satisfaction(P < 0.05).There was no statistical difference in the degree of disease cognition between the two groups(P > 0.05).6.Safety analysis: Tongmai Yangxin Pill has no toxic side effects,and no adverse drug reactions occurred during treatment,showing good safety.Research Conclusions:On the basis of conventional western medicine treatment with qi and square pulse yangxin pill,can effectively improve the PCI postoperative coronary heart disease qi and Yin deficiency type of TCM syndrome in patients with unstable angina,angina symptoms,limited physical activity levels,stabilization state of angina,angina attack situation,treatment satisfaction,improve patient quality of life,and good security. |
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