| Objective:Chronic obstructive pulmonary disease(COPD)is characterized by persistent airflow limitation,chronic cough or Sputum production,and dyspnea.It is a common heterogeneous disease that can be prevented and treated.Clinicians pay more attention to the changes of COPD patients during the day,and pay less attention to the symptoms and progress of COPD at night.Insomnia can significantly affect the course and prognosis of COPD patients.This project hopes to study the efficacy and safety of Huangqin Wendan Decoction Combined with auricular point pressing beans in the treatment of AECOPD and insomnia,make the best of traditional Chinese medicine in basic healthcare,improve their sleep quality,relieve their clinical symptoms,improve their quality of life,improve their prognosis,reduce their pain,and provide reference for the clinical treatment of COPD and insomnia.Method:In this study,60 patients with AECOPD complicated with insomnia(phlegm heat accumulation in lung syndrome)who met the inclusion criteria and passed the exclusion criteria were selected as the clinical observation objects.According to the random envelope method,they were divided into experimental group(n = 30)and control group(n = 30).The patients in control group were given oxygen therapy,antibiotic therapy,atomization antispasmodic and antiasthmatic therapy,systemic glucocorticoid as needed,and other auxiliary support treatment.The experimental group was treated with Huangqin Wendan Decoction plus and auricular point pressing beans on the basis of conventional western medicine treatment in control group,and the observation effect was 2weeks.The mMRC Questionnaire,COPD assessment test scale(CAT score),TCM syndrome score,Pittsburgh sleep quality index(PSQI)and insomnia severity score(ISI)of the patients in experimental group and control group before and after treatment were observed.The observation index data were collected on the first day and two weeks before treatment,and then analyzed by spss26.0 statistical data.The guiding principles for clinical research of new drugs of traditional Chinese medicine were formulated,and the clinical therapeutic efficiency was calculated.Result:1.This study included 60 patients with AECOPD and insomnia,30 cases in experimental group,(drop 3 cases),30 cases in control group,(drop1 case).Before treatment,there was no significant difference in age,gender,course of disease,severity of lung function,CAT score,mMRC,TCM syndrome score,PSQI,ISI between the two groups(P > 0.05),which could be compared statistically.2.After treatment,the scores of mMRC and CAT in experimental group and control group were significantly lower than those before treatment(P < 0.01).After treatment,The mMRC and CAT of experimental group were significantly lower than those of control group(P < 0.01).3.After treatment,the main symptom scores of experimental group and control group: cough,expectoration,wheezing,difficulty in sleeping,easy to wake up after treatment were decreased compared with those before treatment,with significant statistical significance(P < 0.01);the difference of main symptom scores of the experimental group was higher than that of the control group,with statistical significance(P < 0.05),that is,the effect of main symptom score decrease of experimental group after treatment was better than that of control group.Compared with control group before treatment,the symptom scores of control group: upset,dry mouth and bitter mouth,chest tightness,chest pain,decreased significantly,the difference was statistically significant(P < 0.01);the symptom scores of dry stool,red tongue and greasy fur did not decrease,the difference was not statistically significant(P > 0.05).Compared with before treatment,the scores of secondary symptoms in experimental group decreased significantly(P < 0.01).Compared with control group,the scores of upset,dry mouth and bitter mouth,dry stool,red tongue and greasy fur in the experimental group were higher than those in control group,the differences were statistically significant(P < 0.05),but the scores of chest tightness and chest pain were not statistically significant(P > 0.05).4.After treatment,the PSQI score and ISI score of experimental group were lower than those of control group(P < 0.01).Subjective sleep quality,sleep latency,total sleep time,sleep efficiency,sleep disorders,daytime dysfunction score of each sub item of PSQI were significantly decreased in the two groups(P < 0.01).Compared with control group,the scores of subjective sleep quality,the total sleep time,sleep disorder and daytime dysfunction were significantly decreased in experimental group(P < 0.05),and the total sleep time and sleep efficiency were significantly decreased It was more significant(P < 0.01).5.There were 27 cases in experimental group,the total effective rate was 96.30%,and the marked effective rate was 74.07%;there were 29 cases in the control group,the total effective rate was 82.75%,and the marked effective rate was 41.38%.The difference of clinical efficacy between the two groups was statistically significant(P < 0.05),and the treatment effect of experimental group was better than that of control group.Conclusion:The clinical effect of Huangqin Wendan Decoction Combined with auricular point pressing beans in the treatment of COPD and insomnia is significant,which is better than the conventional western medicine treatment alone;it can reduce the TCM syndrome score of COPD and insomnia patients,reduce the mMRC,the CAT,improve the respiratory symptoms of patients with cough,expectoration and wheezing,improve the quality of life;it can reduce the PSQI score and ISI score of COPD and insomnia patients,improve sleep efficiency and prolong sleep time.Huangqin Wendan Decoction Combined with auricular point pressing beans is safe and reliable,which is worthy of clinical promotion. |
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